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A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Author

Listed:
  • Angkana T. Huang

    (University of Florida
    University of Florida
    Department of Virology, Armed Forces Research Institute of Medical Sciences)

  • Bernardo Garcia-Carreras

    (University of Florida
    University of Florida)

  • Matt D. T. Hitchings

    (University of Florida
    University of Florida)

  • Bingyi Yang

    (University of Florida
    University of Florida)

  • Leah C. Katzelnick

    (University of Florida
    University of Florida)

  • Susan M. Rattigan

    (University of Florida
    University of Florida)

  • Brooke A. Borgert

    (University of Florida
    University of Florida)

  • Carlos A. Moreno

    (University of Florida
    University of Florida)

  • Benjamin D. Solomon

    (National Human Genome Research Institute, National Institutes of Health)

  • Luke Trimmer-Smith

    (University of Florida
    University of Florida)

  • Veronique Etienne

    (University of Florida
    University of Florida)

  • Isabel Rodriguez-Barraquer

    (University of California)

  • Justin Lessler

    (Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health)

  • Henrik Salje

    (University of Florida
    University of Cambridge
    Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur)

  • Donald S. Burke

    (University of Pittsburgh)

  • Amy Wesolowski

    (Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health)

  • Derek A. T. Cummings

    (University of Florida
    University of Florida)

Abstract

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

Suggested Citation

  • Angkana T. Huang & Bernardo Garcia-Carreras & Matt D. T. Hitchings & Bingyi Yang & Leah C. Katzelnick & Susan M. Rattigan & Brooke A. Borgert & Carlos A. Moreno & Benjamin D. Solomon & Luke Trimmer-Sm, 2020. "A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18450-4
    DOI: 10.1038/s41467-020-18450-4
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    Cited by:

    1. Tim K. Tsang & Can Wang & Bingyi Yang & Simon Cauchemez & Benjamin J. Cowling, 2021. "Using secondary cases to characterize the severity of an emerging or re-emerging infection," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Tiago Fazolo & Karina Lima & Julia C. Fontoura & Priscila Oliveira Souza & Gabriel Hilario & Renata Zorzetto & Luiz Rodrigues Júnior & Veridiane Maria Pscheidt & Jayme Castilhos Ferreira Neto & Alisso, 2021. "Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Yvonne M. Mueller & Thijs J. Schrama & Rik Ruijten & Marco W. J. Schreurs & Dwin G. B. Grashof & Harmen J. G. van de Werken & Giovanna Jona Lasinio & Daniel Álvarez-Sierra & Caoimhe H. Kiernan & Melis, 2022. "Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Meriem Bekliz & Kenneth Adea & Pauline Vetter & Christiane S. Eberhardt & Krisztina Hosszu-Fellous & Diem-Lan Vu & Olha Puhach & Manel Essaidi-Laziosi & Sophie Waldvogel-Abramowski & Caroline Stephan , 2022. "Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    6. Irene A. Abela & Chloé Pasin & Magdalena Schwarzmüller & Selina Epp & Michèle E. Sickmann & Merle M. Schanz & Peter Rusert & Jacqueline Weber & Stefan Schmutz & Annette Audigé & Liridona Maliqi & Anni, 2021. "Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    7. Kevin J. Kramer & Erin M. Wilfong & Kelsey Voss & Sierra M. Barone & Andrea R. Shiakolas & Nagarajan Raju & Caroline E. Roe & Naveenchandra Suryadevara & Lauren M. Walker & Steven C. Wall & Ariana Pau, 2022. "Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    8. Chunyan Wang & Emma L. Hesketh & Tatiana M. Shamorkina & Wentao Li & Peter J. Franken & Dubravka Drabek & Rien Haperen & Sarah Townend & Frank J. M. Kuppeveld & Frank Grosveld & Neil A. Ranson & Joost, 2022. "Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. M. Alper Çenesiz & Luís Guimarães, 2022. "COVID‐19: What if immunity wanes?," Canadian Journal of Economics/Revue canadienne d'économique, John Wiley & Sons, vol. 55(S1), pages 626-664, February.

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