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Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

Author

Listed:
  • Shelly J. Robertson

    (National Institute of Allergy and Infectious Diseases, NIH
    National Institute of Allergy and Infectious Diseases, NIH)

  • Olivia Bedard

    (The Jackson Laboratory)

  • Kristin L. McNally

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Carl Shaia

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Chad S. Clancy

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Matthew Lewis

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Rebecca M. Broeckel

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Abhilash I. Chiramel

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Jeffrey G. Shannon

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Gail L. Sturdevant

    (National Institute of Allergy and Infectious Diseases, NIH
    National Institute of Allergy and Infectious Diseases, NIH)

  • Rebecca Rosenke

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Sarah L. Anzick

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Elvira Forte

    (The Jackson Laboratory
    Springer Nature)

  • Christoph Preuss

    (The Jackson Laboratory)

  • Candice N. Baker

    (The Jackson Laboratory)

  • Jeffrey M. Harder

    (The Jackson Laboratory)

  • Catherine Brunton

    (The Jackson Laboratory)

  • Steven Munger

    (The Jackson Laboratory)

  • Daniel P. Bruno

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Justin B. Lack

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Jacqueline M. Leung

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Amirhossein Shamsaddini

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Paul Gardina

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Daniel E. Sturdevant

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Jian Sun

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Craig Martens

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Steven M. Holland

    (National Institute of Allergy and Infectious Diseases, NIH)

  • Nadia A. Rosenthal

    (The Jackson Laboratory
    Imperial College London)

  • Sonja M. Best

    (National Institute of Allergy and Infectious Diseases, NIH
    National Institute of Allergy and Infectious Diseases, NIH)

Abstract

Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and clinical outcomes observed in humans are needed. We report a mouse panel comprising the genetically diverse Collaborative Cross (CC) founder strains crossed to human ACE2 transgenic mice (K18-hACE2) that confers susceptibility to SARS-CoV-2. Infection of CC x K18-hACE2 resulted in a spectrum of survival, viral replication kinetics, and immune profiles. Importantly, in contrast to the K18-hACE2 model, early type I interferon (IFN-I) and regulated proinflammatory responses were required for control of SARS-CoV-2 replication in PWK x K18-hACE2 mice that were highly resistant to disease. Thus, virus dynamics and inflammation observed in COVID-19 can be modeled in diverse mouse strains that provide a genetically tractable platform for understanding anti-coronavirus immunity.

Suggested Citation

  • Shelly J. Robertson & Olivia Bedard & Kristin L. McNally & Carl Shaia & Chad S. Clancy & Matthew Lewis & Rebecca M. Broeckel & Abhilash I. Chiramel & Jeffrey G. Shannon & Gail L. Sturdevant & Rebecca , 2023. "Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40076-5
    DOI: 10.1038/s41467-023-40076-5
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