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Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Author

Listed:
  • Lucie Bernard-Raichon

    (New York University Grossman School of Medicine)

  • Mericien Venzon

    (New York University Grossman School of Medicine
    New York University Grossman School of Medicine)

  • Jon Klein

    (Yale School of Medicine)

  • Jordan E. Axelrad

    (New York University Grossman School of Medicine)

  • Chenzhen Zhang

    (New York University Grossman School of Medicine)

  • Alexis P. Sullivan

    (New York University Grossman School of Medicine)

  • Grant A. Hussey

    (New York University Grossman School of Medicine)

  • Arnau Casanovas-Massana

    (Yale School of Public Health)

  • Maria G. Noval

    (New York University Grossman School of Medicine)

  • Ana M. Valero-Jimenez

    (New York University Grossman School of Medicine)

  • Juan Gago

    (New York University Grossman School of Medicine
    New York University Grossman School of Medicine)

  • Gregory Putzel

    (New York University Grossman School of Medicine
    New York University School of Medicine)

  • Alejandro Pironti

    (New York University Grossman School of Medicine
    New York University School of Medicine)

  • Evan Wilder

    (New York University Grossman School of Medicine)

  • Lorna E. Thorpe

    (New York University Grossman School of Medicine
    New York University School of Medicine)

  • Dan R. Littman

    (New York University Grossman School of Medicine
    Howard Hughes Medical Institute)

  • Meike Dittmann

    (New York University Grossman School of Medicine)

  • Kenneth A. Stapleford

    (New York University Grossman School of Medicine)

  • Bo Shopsin

    (New York University Grossman School of Medicine
    New York University School of Medicine
    New York University Grossman School of Medicine)

  • Victor J. Torres

    (New York University Grossman School of Medicine
    New York University School of Medicine)

  • Albert I. Ko

    (Yale School of Public Health)

  • Akiko Iwasaki

    (Yale School of Medicine
    Howard Hughes Medical Institute)

  • Ken Cadwell

    (New York University Grossman School of Medicine
    New York University Grossman School of Medicine
    New York University Grossman School of Medicine
    New York University School of Medicine)

  • Jonas Schluter

    (New York University Grossman School of Medicine
    New York University Grossman School of Medicine
    New York University School of Medicine)

Abstract

Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.

Suggested Citation

  • Lucie Bernard-Raichon & Mericien Venzon & Jon Klein & Jordan E. Axelrad & Chenzhen Zhang & Alexis P. Sullivan & Grant A. Hussey & Arnau Casanovas-Massana & Maria G. Noval & Ana M. Valero-Jimenez & Jua, 2022. "Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33395-6
    DOI: 10.1038/s41467-022-33395-6
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    References listed on IDEAS

    as
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