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Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Author

Listed:
  • Clovis S. Palmer

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Chrysostomos Perdios

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Mohamed Abdel-Mohsen

    (The Wistar Institute)

  • Joseph Mudd

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Prasun K. Datta

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Nicholas J. Maness

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Gabrielle Lehmicke

    (Tulane National Primate Research Center)

  • Nadia Golden

    (Tulane National Primate Research Center)

  • Linh Hellmers

    (Tulane National Primate Research Center)

  • Carol Coyne

    (Tulane National Primate Research Center)

  • Kristyn Moore Green

    (Tulane National Primate Research Center)

  • Cecily Midkiff

    (Tulane National Primate Research Center)

  • Kelsey Williams

    (Tulane National Primate Research Center)

  • Rafael Tiburcio

    (University of San Francisco)

  • Marissa Fahlberg

    (Tulane National Primate Research Center)

  • Kyndal Boykin

    (Tulane National Primate Research Center)

  • Carys Kenway

    (Tulane National Primate Research Center)

  • Kasi Russell-Lodrigue

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Angela Birnbaum

    (Tulane National Primate Research Center)

  • Rudolf Bohm

    (Oregon Health and Science University)

  • Robert Blair

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Jason P. Dufour

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Tracy Fischer

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Ahmad A. Saied

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Jay Rappaport

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

Abstract

Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys. Using this model, we identify a dysregulated blood chemokine signature during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. Hyperglycemia also correlates with liver glycogen levels, but there is no evidence of substantial long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection. Together, these data suggest that the African green monkey model exhibits important similarities to humans and can be utilized to assess therapeutic candidates to combat COVID-related metabolic defects.

Suggested Citation

  • Clovis S. Palmer & Chrysostomos Perdios & Mohamed Abdel-Mohsen & Joseph Mudd & Prasun K. Datta & Nicholas J. Maness & Gabrielle Lehmicke & Nadia Golden & Linh Hellmers & Carol Coyne & Kristyn Moore Gr, 2024. "Non-human primate model of long-COVID identifies immune associates of hyperglycemia," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50339-4
    DOI: 10.1038/s41467-024-50339-4
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    References listed on IDEAS

    as
    1. Sydney R. Stein & Sabrina C. Ramelli & Alison Grazioli & Joon-Yong Chung & Manmeet Singh & Claude Kwe Yinda & Clayton W. Winkler & Junfeng Sun & James M. Dickey & Kris Ylaya & Sung Hee Ko & Andrew P. , 2022. "SARS-CoV-2 infection and persistence in the human body and brain at autopsy," Nature, Nature, vol. 612(7941), pages 758-763, December.
    2. M. D. Fahlberg & R. V. Blair & L. A. Doyle-Meyers & C. C. Midkiff & G. Zenere & K. E. Russell-Lodrigue & C. J. Monjure & E. H. Haupt & T. P. Penney & G. Lehmicke & B. M. Threeton & N. Golden & P. K. D, 2020. "Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    3. Carolina Lucas & Patrick Wong & Jon Klein & Tiago B. R. Castro & Julio Silva & Maria Sundaram & Mallory K. Ellingson & Tianyang Mao & Ji Eun Oh & Benjamin Israelow & Takehiro Takahashi & Maria Tokuyam, 2020. "Longitudinal analyses reveal immunological misfiring in severe COVID-19," Nature, Nature, vol. 584(7821), pages 463-469, August.
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