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Differential stability of task variable representations in retrosplenial cortex

Author

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  • Luis M. Franco

    (University of California, Santa Barbara
    University of Oregon)

  • Michael J. Goard

    (University of California, Santa Barbara
    University of California, Santa Barbara
    University of California, Santa Barbara)

Abstract

Cortical neurons store information across different timescales, from seconds to years. Although information stability is variable across regions, it can vary within a region as well. Association areas are known to multiplex behaviorally relevant variables, but the stability of their representations is not well understood. Here, we longitudinally recorded the activity of neuronal populations in the mouse retrosplenial cortex (RSC) during the performance of a context-choice association task. We found that the activity of neurons exhibits different levels of stability across days. Using linear classifiers, we quantified the stability of three task-relevant variables. We find that RSC representations of context and trial outcome display higher stability than motor choice, both at the single cell and population levels. Together, our findings show an important characteristic of association areas, where diverse streams of information are stored with varying levels of stability, which may balance representational reliability and flexibility according to behavioral demands.

Suggested Citation

  • Luis M. Franco & Michael J. Goard, 2024. "Differential stability of task variable representations in retrosplenial cortex," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51227-7
    DOI: 10.1038/s41467-024-51227-7
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    References listed on IDEAS

    as
    1. Tyler D. Marks & Michael J. Goard, 2021. "Author Correction: Stimulus-dependent representational drift in primary visual cortex," Nature Communications, Nature, vol. 12(1), pages 1-1, December.
    2. Johannes Friedrich & Pengcheng Zhou & Liam Paninski, 2017. "Fast online deconvolution of calcium imaging data," PLOS Computational Biology, Public Library of Science, vol. 13(3), pages 1-26, March.
    3. Eun Jung Hwang & Jeffrey E. Dahlen & Madan Mukundan & Takaki Komiyama, 2017. "History-based action selection bias in posterior parietal cortex," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    4. Ji Xia & Tyler D. Marks & Michael J. Goard & Ralf Wessel, 2021. "Stable representation of a naturalistic movie emerges from episodic activity with gain variability," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Carl E. Schoonover & Sarah N. Ohashi & Richard Axel & Andrew J. P. Fink, 2021. "Representational drift in primary olfactory cortex," Nature, Nature, vol. 594(7864), pages 541-546, June.
    6. Shinichiro Kira & Houman Safaai & Ari S. Morcos & Stefano Panzeri & Christopher D. Harvey, 2023. "A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions," Nature Communications, Nature, vol. 14(1), pages 1-28, December.
    7. Dun Mao & Steffen Kandler & Bruce L. McNaughton & Vincent Bonin, 2017. "Sparse orthogonal population representation of spatial context in the retrosplenial cortex," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    8. William A. Liberti & Tobias A. Schmid & Angelo Forli & Madeleine Snyder & Michael M. Yartsev, 2022. "A stable hippocampal code in freely flying bats," Nature, Nature, vol. 604(7904), pages 98-103, April.
    9. Weilun Sun & Ilseob Choi & Stoyan Stoyanov & Oleg Senkov & Evgeni Ponimaskin & York Winter & Janelle M. P. Pakan & Alexander Dityatev, 2021. "Context value updating and multidimensional neuronal encoding in the retrosplenial cortex," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    10. Richard F Betzel & Katherine C Wood & Christopher Angeloni & Maria Neimark Geffen & Danielle S Bassett, 2019. "Stability of spontaneous, correlated activity in mouse auditory cortex," PLOS Computational Biology, Public Library of Science, vol. 15(12), pages 1-25, December.
    11. William A. Liberti & Tobias A. Schmid & Angelo Forli & Madeleine Snyder & Michael M. Yartsev, 2022. "Publisher Correction: A stable hippocampal code in freely flying bats," Nature, Nature, vol. 606(7914), pages 6-6, June.
    12. Seung Wook Oh & Julie A. Harris & Lydia Ng & Brent Winslow & Nicholas Cain & Stefan Mihalas & Quanxin Wang & Chris Lau & Leonard Kuan & Alex M. Henry & Marty T. Mortrud & Benjamin Ouellette & Thuc Ngh, 2014. "A mesoscale connectome of the mouse brain," Nature, Nature, vol. 508(7495), pages 207-214, April.
    13. Thomas Hainmueller & Marlene Bartos, 2018. "Parallel emergence of stable and dynamic memory engrams in the hippocampus," Nature, Nature, vol. 558(7709), pages 292-296, June.
    14. Han Chin Wang & Amy M. LeMessurier & Daniel E. Feldman, 2022. "Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    15. Tyler D. Marks & Michael J. Goard, 2021. "Stimulus-dependent representational drift in primary visual cortex," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    16. Soyoun Kim & Dajung Jung & Sébastien Royer, 2020. "Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
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