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Sparse orthogonal population representation of spatial context in the retrosplenial cortex

Author

Listed:
  • Dun Mao

    (Neuro-Electronics Research Flanders
    University of Lethbridge)

  • Steffen Kandler

    (Neuro-Electronics Research Flanders
    Imec)

  • Bruce L. McNaughton

    (Neuro-Electronics Research Flanders
    University of Lethbridge)

  • Vincent Bonin

    (Neuro-Electronics Research Flanders
    Imec
    VIB
    Department of Biology, KU Leuven)

Abstract

Sparse orthogonal coding is a key feature of hippocampal neural activity, which is believed to increase episodic memory capacity and to assist in navigation. Some retrosplenial cortex (RSC) neurons convey distributed spatial and navigational signals, but place-field representations such as observed in the hippocampus have not been reported. Combining cellular Ca2+ imaging in RSC of mice with a head-fixed locomotion assay, we identified a population of RSC neurons, located predominantly in superficial layers, whose ensemble activity closely resembles that of hippocampal CA1 place cells during the same task. Like CA1 place cells, these RSC neurons fire in sequences during movement, and show narrowly tuned firing fields that form a sparse, orthogonal code correlated with location. RSC ‘place’ cell activity is robust to environmental manipulations, showing partial remapping similar to that observed in CA1. This population code for spatial context may assist the RSC in its role in memory and/or navigation.

Suggested Citation

  • Dun Mao & Steffen Kandler & Bruce L. McNaughton & Vincent Bonin, 2017. "Sparse orthogonal population representation of spatial context in the retrosplenial cortex," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00180-9
    DOI: 10.1038/s41467-017-00180-9
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    Cited by:

    1. Luis M. Franco & Michael J. Goard, 2024. "Differential stability of task variable representations in retrosplenial cortex," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Xu Han & Ben Vermaercke & Vincent Bonin, 2022. "Diversity of spatiotemporal coding reveals specialized visual processing streams in the mouse cortex," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. HaoRan Chang & Ingrid M. Esteves & Adam R. Neumann & Majid H. Mohajerani & Bruce L. McNaughton, 2023. "Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Weilun Sun & Ilseob Choi & Stoyan Stoyanov & Oleg Senkov & Evgeni Ponimaskin & York Winter & Janelle M. P. Pakan & Alexander Dityatev, 2021. "Context value updating and multidimensional neuronal encoding in the retrosplenial cortex," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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