The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
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DOI: 10.1038/s41467-021-25966-w
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- Dhiman Ghosh & Felix Torres & Matthias M. Schneider & Dzmitry Ashkinadze & Harindranath Kadavath & Yanick Fleischmann & Simon Mergenthal & Peter Güntert & Georg Krainer & Ewa A. Andrzejewska & Lily Li, 2024. "The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- S. M. Ayala Mariscal & M. L. Pigazzini & Y. Richter & M. Özel & I. L. Grothaus & J. Protze & K. Ziege & M. Kulke & M. ElBediwi & J. V. Vermaas & L. Colombi Ciacchi & S. Köppen & F. Liu & J. Kirstein, 2022. "Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT," Nature Communications, Nature, vol. 13(1), pages 1-25, December.
- Vrinda Sant & Dirk Matthes & Hisham Mazal & Leif Antonschmidt & Franz Wieser & Kumar T. Movellan & Kai Xue & Evgeny Nimerovsky & Marianna Stampolaki & Magdeline Nathan & Dietmar Riedel & Stefan Becker, 2025. "Lipidic folding pathway of α-Synuclein via a toxic oligomer," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
- Itika Saha & Patricia Yuste-Checa & Miguel Silva Padilha & Qiang Guo & Roman Körner & Hauke Holthusen & Victoria A. Trinkaus & Irina Dudanova & Rubén Fernández-Busnadiego & Wolfgang Baumeister & David, 2023. "The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Georg Krainer & Raphael P. B. Jacquat & Matthias M. Schneider & Timothy J. Welsh & Jieyuan Fan & Quentin A. E. Peter & Ewa A. Andrzejewska & Greta Šneiderienė & Magdalena A. Czekalska & Hannes Ausserw, 2024. "Single-molecule digital sizing of proteins in solution," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
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