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Performing Arm-Based Network Meta-Analysis in R with the pcnetmeta Package

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  • Lin, Lifeng
  • Zhang, Jing
  • Hodges, James S.
  • Chu, Haitao

Abstract

Network meta-analysis is a powerful approach for synthesizing direct and indirect evidence about multiple treatment comparisons from a collection of independent studies. At present, the most widely used method in network meta-analysis is contrast-based, in which a baseline treatment needs to be specified in each study, and the analysis focuses on modeling relative treatment effects (typically log odds ratios). However, populationaveraged treatment-specific parameters, such as absolute risks, cannot be estimated by this method without an external data source or a separate model for a reference treatment. Recently, an arm-based network meta-analysis method has been proposed, and the R package pcnetmeta provides user-friendly functions for its implementation. This package estimates both absolute and relative effects, and can handle binary, continuous, and count outcomes.

Suggested Citation

  • Lin, Lifeng & Zhang, Jing & Hodges, James S. & Chu, Haitao, 2017. "Performing Arm-Based Network Meta-Analysis in R with the pcnetmeta Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 80(i05).
  • Handle: RePEc:jss:jstsof:v:080:i05
    DOI: http://hdl.handle.net/10.18637/jss.v080.i05
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    References listed on IDEAS

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    1. Pedro Saramago & Ling-Hsiang Chuang & Marta Soares, 2014. "Network Meta-Analysis of (Individual Patient) Time to Event Data Alongside (Aggregate) Count Data," Working Papers 095cherp, Centre for Health Economics, University of York.
    2. Lu, Guobing & Ades, A.E., 2006. "Assessing Evidence Inconsistency in Mixed Treatment Comparisons," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 447-459, June.
    3. Ian White, 2017. "NETWORK: Stata module to perform network meta-analysis," Statistical Software Components S458319, Boston College Department of Economics, revised 07 Apr 2018.
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    Cited by:

    1. Fahad M. Al Amer & Christopher G. Thompson & Lifeng Lin, 2021. "Bayesian Methods for Meta-Analyses of Binary Outcomes: Implementations, Examples, and Impact of Priors," IJERPH, MDPI, vol. 18(7), pages 1-14, March.
    2. Mohamed A. Hassan & Wenxi Liu & Daniel J. McDonough & Xiwen Su & Zan Gao, 2022. "Comparative Effectiveness of Physical Activity Intervention Programs on Motor Skills in Children and Adolescents: A Systematic Review and Network Meta-Analysis," IJERPH, MDPI, vol. 19(19), pages 1-12, September.

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