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Effect of AcrySof versus other intraocular lens properties on the risk of Nd:YAG capsulotomy after cataract surgery: A systematic literature review and network meta-analysis

Author

Listed:
  • Howard Thom
  • Frank Ender
  • Saisudha Samavedam
  • Caridad Perez Vivez
  • Subhajit Gupta
  • Mukesh Dhariwal
  • Jan de Haan
  • Derek O’Boyle

Abstract

Objective: The purpose of this study was to evaluate the impact of different intraocular lens materials (IOL) and optic edge designs on the incidence of Nd:YAG laser capsulotomy. Methods: Randomized controlled trials (RCTs) reporting incidence of Nd:YAG capsulotomy in patients with monofocal IOLs were identified for systematic literature review (SLR) using Cochrane methodology. A network meta-analysis was conducted under a Bayesian framework. Mean hazard ratios (HRs), 95% credible intervals, and one-sided p-values were estimated for Nd:YAG capsulotomy incidence by comparing AcrySof IOLs with a group of non-AcrySof hydrophobic acrylic, hydrophilic acrylic, silicone, and PMMA IOLs. Sensitivity analysis was conducted comparing the risk of Nd:YAG capsulotomy between sharp- and round-edged designs of the above IOLs. Results: AcrySof IOLs had a lower risk of Nd:YAG capsulotomy compared to hydrophobic acrylic (HR: 2.68; 95% CrI: 1.41, 4.77; p

Suggested Citation

  • Howard Thom & Frank Ender & Saisudha Samavedam & Caridad Perez Vivez & Subhajit Gupta & Mukesh Dhariwal & Jan de Haan & Derek O’Boyle, 2019. "Effect of AcrySof versus other intraocular lens properties on the risk of Nd:YAG capsulotomy after cataract surgery: A systematic literature review and network meta-analysis," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-15, August.
    • Handle: RePEc:plo:pone00:0220498
    DOI: 10.1371/journal.pone.0220498
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    References listed on IDEAS

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