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Sensitivity of Survival Analysis Metrics

Author

Listed:
  • Iulii Vasilev

    (Computer Science Department, Lomonosov Moscow State University, Vorobjovy Gory, 119899 Moscow, Russia)

  • Mikhail Petrovskiy

    (Computer Science Department, Lomonosov Moscow State University, Vorobjovy Gory, 119899 Moscow, Russia)

  • Igor Mashechkin

    (Computer Science Department, Lomonosov Moscow State University, Vorobjovy Gory, 119899 Moscow, Russia)

Abstract

Survival analysis models allow for predicting the probability of an event over time. The specificity of the survival analysis data includes the distribution of events over time and the proportion of classes. Late events are often rare and do not correspond to the main distribution and strongly affect the quality of the models and quality assessment. In this paper, we identify four cases of excessive sensitivity of survival analysis metrics and propose methods to overcome them. To set the equality of observation impacts, we adjust the weights of events based on target time and censoring indicator. According to the sensitivity of metrics, A U P R C (area under Precision-Recall curve) is best suited for assessing the quality of survival models, and other metrics are used as loss functions. To evaluate the influence of the loss function, the B a g g i n g model uses ones to select the size and hyperparameters of the ensemble. The experimental study included eight real medical datasets. The proposed modifications of I B S (Integrated Brier Score) improved the quality of B a g g i n g compared to the classical loss functions. In addition, in seven out of eight datasets, the B a g g i n g with new loss functions outperforms the existing models of the scikit-survival library.

Suggested Citation

  • Iulii Vasilev & Mikhail Petrovskiy & Igor Mashechkin, 2023. "Sensitivity of Survival Analysis Metrics," Mathematics, MDPI, vol. 11(20), pages 1-34, October.
  • Handle: RePEc:gam:jmathe:v:11:y:2023:i:20:p:4246-:d:1257599
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    References listed on IDEAS

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    1. Uno, Hajime & Cai, Tianxi & Tian, Lu & Wei, L.J., 2007. "Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 527-537, June.
    2. Patrick J. Heagerty & Yingye Zheng, 2005. "Survival Model Predictive Accuracy and ROC Curves," Biometrics, The International Biometric Society, vol. 61(1), pages 92-105, March.
    3. Patrick Royston & Paul C. Lambert, 2011. "Flexible Parametric Survival Analysis Using Stata: Beyond the Cox Model," Stata Press books, StataCorp LP, number fpsaus, March.
    4. Michael Brendel & Arnold Janssen & Claus-Dieter Mayer & Markus Pauly, 2014. "Weighted Logrank Permutation Tests for Randomly Right Censored Life Science Data," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 41(3), pages 742-761, September.
    5. Lee, Seung-Hwan, 2007. "On the versatility of the combination of the weighted log-rank statistics," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 6557-6564, August.
    6. Håvard Kvamme & Ørnulf Borgan, 2021. "Continuous and discrete-time survival prediction with neural networks," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(4), pages 710-736, October.
    7. Pinar Gunel Karadeniz & Ilker Ercan, 2017. "Examining Tests For Comparing Survival Curves With Right Censored Data," Statistics in Transition New Series, Polish Statistical Association, vol. 18(2), pages 311-328, June.
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