IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i12p7077-d834916.html
   My bibliography  Save this article

Contrast Media Adverse Drug Reactions in Highly Polluted Environment

Author

Listed:
  • Natalia Sauer

    (Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wrocław, Poland
    These authors contributed equally to this work.)

  • Wojciech Szlasa

    (Faculty of Medicine, Wroclaw Medical University, 50-367 Wrocław, Poland
    These authors contributed equally to this work.)

  • Laura Jonderko

    (Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wrocław, Poland)

  • Krystyna Głowacka

    (Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wrocław, Poland)

  • Katarzyna Karłowicz-Bodalska

    (Department of Drugs Form Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland)

  • Anna Wiela-Hojeńska

    (Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wrocław, Poland)

Abstract

Iodinated- (ICM) and gadolinium-based (GCM) contrast media are used in radiology imaging techniques, such as computer tomography (CT) and magnetic resonance (MR), respectively. The paper aims to analyze the adverse drug reactions of ICM and GCM on different sites of the body in a highly polluted environment. We analyzed the pharmacovigilance in contrast media on the basis of reports submitted to the Regional Center for Monitoring of Adverse Drug Reactions (ADR) at the Department of Clinical Pharmacology in Wrocław. Safety profiles were compared between different ICM and GCM and at the system organ level using the proportional reporting ratio (PRR). We analyzed 124 reports of adverse reactions related to contrast agents between 2006 and 2021. Our findings revealed that ADR combinations occurred more frequently after the use of iodinated contrast agents (72.08%) than gadolinium contrast agents (27.92%). Iomeprol and Iopromide were identified as the most frequently reported media. Each medium presented a different safety profile. Skin disorders are the most common adverse drug reactions among patients using both iodine- and gadolinium-based contrast media. Gadolinium-based contrast agents are characterized by similar organ toxicity. Conversely, iodine-based contrast agents are more diverse—some of which show tissue specificity, such as Iodixanol for the gastrointestinal system or Iohexol for the respiratory tract. This study shows relatively high occurrence of respiratory tract related ADRs in Wrocław. We also prove that it is possible to choose the most optimal contrast agent for patients with specific organ site problems to omit the possible complications.

Suggested Citation

  • Natalia Sauer & Wojciech Szlasa & Laura Jonderko & Krystyna Głowacka & Katarzyna Karłowicz-Bodalska & Anna Wiela-Hojeńska, 2022. "Contrast Media Adverse Drug Reactions in Highly Polluted Environment," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7077-:d:834916
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/12/7077/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/12/7077/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Thomas J. Clough & Lijun Jiang & Ka-Leung Wong & Nicholas J. Long, 2019. "Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. Angelica I. Tiotiu & Plamena Novakova & Denislava Nedeva & Herberto Jose Chong-Neto & Silviya Novakova & Paschalis Steiropoulos & Krzysztof Kowal, 2020. "Impact of Air Pollution on Asthma Outcomes," IJERPH, MDPI, vol. 17(17), pages 1-29, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shilpi Tewari & Nidhi Pandey & Jierui Dong, 2024. "Air Quality Legislation in Australia and Canada—A Review," Challenges, MDPI, vol. 15(4), pages 1-20, November.
    2. Melania Maria Serafini & Ambra Maddalon & Martina Iulini & Valentina Galbiati, 2022. "Air Pollution: Possible Interaction between the Immune and Nervous System?," IJERPH, MDPI, vol. 19(23), pages 1-24, November.
    3. Souad Mahmoud Al Okla & Fatima Al Zahra Khamis Al Rasbi & Hawida Said Al Marhubi & Shima Salim Al Mataani & Yusra Mohammed Al Sawai & Hasa Ibrahim Mohammed & Muna Ali Salim Al Mamari & Salwa Abdullah , 2024. "The Impact of Air Pollution on Asthma Severity among Residents Living near the Main Industrial Complex in Oman: A Cross-Sectional Study," IJERPH, MDPI, vol. 21(5), pages 1-26, April.
    4. Szymon Hoffman & Rafał Jasiński & Janusz Baran, 2024. "Regression Modeling of Daily PM 2.5 Concentrations with a Multilayer Perceptron," Energies, MDPI, vol. 17(9), pages 1-20, May.
    5. Szymon Hoffman & Mariusz Filak & Rafał Jasiński, 2022. "Air Quality Modeling with the Use of Regression Neural Networks," IJERPH, MDPI, vol. 19(24), pages 1-33, December.
    6. Yun-Gi Lee & Pureun-Haneul Lee & Seon-Muk Choi & Min-Hyeok An & An-Soo Jang, 2021. "Effects of Air Pollutants on Airway Diseases," IJERPH, MDPI, vol. 18(18), pages 1-17, September.
    7. Giovanna Cilluffo & Giuliana Ferrante & Nicola Murgia & Rosanna Mancini & Simona Pichini & Giuseppe Cuffari & Vittoria Giudice & Nicolò Tirone & Velia Malizia & Laura Montalbano & Salvatore Fasola & R, 2022. "Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis," IJERPH, MDPI, vol. 19(3), pages 1-14, February.
    8. Miski Aghnia Khairinisa & Winda Ariyani & Yoshito Tsushima & Noriyuki Koibuchi, 2021. "Effects of Gadolinium Deposits in the Cerebellum: Reviewing the Literature from In Vitro Laboratory Studies to In Vivo Human Investigations," IJERPH, MDPI, vol. 18(14), pages 1-12, July.
    9. Yuping Dong & Helin Liu & Tianming Zheng, 2021. "Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto," IJERPH, MDPI, vol. 18(11), pages 1-25, May.
    10. Shereen Elshaer & Lisa J. Martin & Theresa A. Baker & Erin Roberts & Paola Rios-Santiago & Ross Kaufhold & Melinda Butsch Kovacic, 2023. "Environmental Health Knowledge Does Not Necessarily Translate to Action in Youth," IJERPH, MDPI, vol. 20(5), pages 1-14, February.
    11. Angelica Tiotiu & Iulia Ioan & Nathalie Wirth & Rodrigo Romero-Fernandez & Francisco-Javier González-Barcala, 2021. "The Impact of Tobacco Smoking on Adult Asthma Outcomes," IJERPH, MDPI, vol. 18(3), pages 1-12, January.
    12. Pantitcha Thanatrakolsri & Duanpen Sirithian, 2024. "Assessing the Additional Benefits of Thailand’s Approaches to Reduce Motor Vehicle Emissions," Energies, MDPI, vol. 17(10), pages 1-22, May.
    13. Singh, Damini & Gupta, Indrani & Roy, Arjun, 2023. "The association of asthma and air pollution: Evidence from India," Economics & Human Biology, Elsevier, vol. 51(C).
    14. Gabriela Martins Costa Gomes & Wilfried Karmaus & Vanessa E. Murphy & Peter G. Gibson & Elizabeth Percival & Philip M. Hansbro & Malcolm R. Starkey & Joerg Mattes & Adam M. Collison, 2021. "Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles," IJERPH, MDPI, vol. 18(14), pages 1-16, July.
    15. Hélène Niculita-Hirzel, 2022. "Latest Trends in Pollutant Accumulations at Threatening Levels in Energy-Efficient Residential Buildings with and without Mechanical Ventilation: A Review," IJERPH, MDPI, vol. 19(6), pages 1-12, March.
    16. Hanna Maria Elonheimo & Tiina Mattila & Helle Raun Andersen & Beatrice Bocca & Flavia Ruggieri & Elsi Haverinen & Hanna Tolonen, 2022. "Environmental Substances Associated with Chronic Obstructive Pulmonary Disease—A Scoping Review," IJERPH, MDPI, vol. 19(7), pages 1-13, March.
    17. Kelton Mock & Anton M. Palma & Jun Wu & John Billimek & Kim D. Lu, 2022. "Breathing Room: Industrial Zoning and Asthma Incidence Using School District Health Records in the City of Santa Ana, California," IJERPH, MDPI, vol. 19(8), pages 1-12, April.
    18. Tomáš David & Miroslava Šedinová & Aneta Myšková & Jaroslav Kuneš & Lenka Maletínská & Radek Pohl & Martin Dračínský & Helena Mertlíková-Kaiserová & Karel Čížek & Blanka Klepetářová & Miroslava Liteck, 2024. "Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7077-:d:834916. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.