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Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

Author

Listed:
  • Thomas J. Clough

    (Molecular Sciences Research Hub, White City Campus)

  • Lijun Jiang

    (Molecular Sciences Research Hub, White City Campus
    Hong Kong Baptist University)

  • Ka-Leung Wong

    (Hong Kong Baptist University)

  • Nicholas J. Long

    (Molecular Sciences Research Hub, White City Campus)

Abstract

Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.

Suggested Citation

  • Thomas J. Clough & Lijun Jiang & Ka-Leung Wong & Nicholas J. Long, 2019. "Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09342-3
    DOI: 10.1038/s41467-019-09342-3
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    Cited by:

    1. Natalia Sauer & Wojciech Szlasa & Laura Jonderko & Krystyna Głowacka & Katarzyna Karłowicz-Bodalska & Anna Wiela-Hojeńska, 2022. "Contrast Media Adverse Drug Reactions in Highly Polluted Environment," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
    2. Miski Aghnia Khairinisa & Winda Ariyani & Yoshito Tsushima & Noriyuki Koibuchi, 2021. "Effects of Gadolinium Deposits in the Cerebellum: Reviewing the Literature from In Vitro Laboratory Studies to In Vivo Human Investigations," IJERPH, MDPI, vol. 18(14), pages 1-12, July.
    3. Tomáš David & Miroslava Šedinová & Aneta Myšková & Jaroslav Kuneš & Lenka Maletínská & Radek Pohl & Martin Dračínský & Helena Mertlíková-Kaiserová & Karel Čížek & Blanka Klepetářová & Miroslava Liteck, 2024. "Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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