IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i22p12011-d680156.html
   My bibliography  Save this article

Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study

Author

Listed:
  • Marcin Januszewski

    (Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Laura Ziuzia-Januszewska

    (Department of Otolaryngology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Alicja A. Jakimiuk

    (Department of Plastic Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Waldemar Wierzba

    (Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
    Satellite Campus in Warsaw, University of Humanities and Economics, 01-513 Warsaw, Poland)

  • Anna Gluszko

    (Department of Neonatology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Joanna Zytynska-Daniluk

    (Department of Neonatology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Artur J. Jakimiuk

    (Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
    Center for Reproductive Health, Institute of Mother and Child, 01-211 Warsaw, Poland)

Abstract

The COVID-19 pandemic has challenged health systems around the world. Maternal-foetal medicine, which has been particularly affected, must consider scientific data on the physiological processes occurring in the pregnant woman’s body to develop relevant standards of care. Our study retrospectively compared the clinical and laboratory characteristics of 52 COVID-19 pregnant patients with 53 controls. Most of the pregnant patients required medical attention during the third trimester and therefore we propose that vaccination is needed prior to the 30th week of pregnancy. We found no differences between the 2 groups in the course of illness classification system, days of hospital stay, need for oxygen supplementation, need for mechanical ventilation, and ICU admission. Moreover, clinical manifestations and imaging findings were comparable. Pregnant patients needed a greater oxygen flow rate and required high flow oxygen therapy more frequently. Considering pregnancy-related physiological adaptations, we found that COVID-19 infection in pregnant patients is associated with higher levels of inflammatory markers, apart from serum ferritin, than in non-pregnant women, and concluded that biomarkers of cardiac and muscle injury, as well as kidney function, may not be good predictors of COVID-19 clinical course in pregnant patients at the time of admission, but more research needs to be conducted on this topic.

Suggested Citation

  • Marcin Januszewski & Laura Ziuzia-Januszewska & Alicja A. Jakimiuk & Waldemar Wierzba & Anna Gluszko & Joanna Zytynska-Daniluk & Artur J. Jakimiuk, 2021. "Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study," IJERPH, MDPI, vol. 18(22), pages 1-15, November.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:12011-:d:680156
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/22/12011/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/22/12011/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Wenhui Li & Michael J. Moore & Natalya Vasilieva & Jianhua Sui & Swee Kee Wong & Michael A. Berne & Mohan Somasundaran & John L. Sullivan & Katherine Luzuriaga & Thomas C. Greenough & Hyeryun Choe & M, 2003. "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus," Nature, Nature, vol. 426(6965), pages 450-454, November.
    2. Michael C Grant & Luke Geoghegan & Marc Arbyn & Zakaria Mohammed & Luke McGuinness & Emily L Clarke & Ryckie G Wade, 2020. "The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-19, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Olzhas Zhamantayev & Gaukhar Kayupova & Karina Nukeshtayeva & Nurbek Yerdessov & Zhanerke Bolatova & Anar Turmukhambetova, 2023. "COVID-19 Pandemic Impact on the Maternal Mortality in Kazakhstan and Comparison with the Countries in Central Asia," IJERPH, MDPI, vol. 20(3), pages 1-13, January.
    2. Valentin Nicolae Varlas & Roxana Georgiana Borș & Mihaela Plotogea & Madalina Iordache & Claudia Mehedințu & Monica Mihaela Cîrstoiu, 2023. "Thromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue," IJERPH, MDPI, vol. 20(3), pages 1-19, January.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Behrooz Darbani, 2020. "The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    2. Shanlin Ke & Scott T. Weiss & Yang-Yu Liu, 2022. "Dissecting the role of the human microbiome in COVID-19 via metagenome-assembled genomes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Indrikis A. Krams & Priit Jõers & Severi Luoto & Giedrius Trakimas & Vilnis Lietuvietis & Ronalds Krams & Irena Kaminska & Markus J. Rantala & Tatjana Krama, 2021. "The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries," IJERPH, MDPI, vol. 18(3), pages 1-10, January.
    4. Najeeb Ullah & Khurshid Ahmad Khan & Javeid Iqbal & Asim Rana & Bilal Bin Younis & Mohsin Asif & Aijaz Zeeshan Khan Chachar & Falak shan, 2020. "Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore," International Journal of Sciences, Office ijSciences, vol. 9(11), pages 31-34, November.
    5. Oliver Viera-Segura & Natali Vega-Magaña & Mariel García-Chagollán & Marcela Peña-Rodríguez & Germán Muñoz-Sánchez & Ahtziri Socorro Carranza-Aranda & Iris Monserrat Llamas-Covarrubias & Moisés Ramos-, 2021. "A Comprehensive Descriptive Epidemiological and Clinical Analysis of SARS-CoV-2 in West-Mexico during COVID-19 Pandemic 2020," IJERPH, MDPI, vol. 18(20), pages 1-13, October.
    6. Ravindra B. Malabadi & Neelambika T. Meti & Raju K. Chalannavar, 2021. "Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19)," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 8(2), pages 135-165, February.
    7. Milad Haghani & Pegah Varamini, 2021. "Temporal evolution, most influential studies and sleeping beauties of the coronavirus literature," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 7005-7050, August.
    8. Nikola Anđelić & Sandi Baressi Šegota & Ivan Lorencin & Zdravko Jurilj & Tijana Šušteršič & Anđela Blagojević & Alen Protić & Tomislav Ćabov & Nenad Filipović & Zlatan Car, 2021. "Estimation of COVID-19 Epidemiology Curve of the United States Using Genetic Programming Algorithm," IJERPH, MDPI, vol. 18(3), pages 1-26, January.
    9. Diego Fernández-Lázaro & Jerónimo J. González-Bernal & Nerea Sánchez-Serrano & Lourdes Jiménez Navascués & Ana Ascaso-del-Río & Juan Mielgo-Ayuso, 2020. "Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?," IJERPH, MDPI, vol. 17(22), pages 1-13, November.
    10. Weiwei Ji & Qi Peng & Xueqiong Fang & Zehou Li & Yaxin Li & Cunfa Xu & Shuqing Zhao & Jizong Li & Rong Chen & Guoxiang Mo & Zhanyong Wei & Ying Xu & Bin Li & Shuijun Zhang, 2022. "Structures of a deltacoronavirus spike protein bound to porcine and human receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    11. Caterina Alacevich & Inna Thalmann & Catia Nicodemo & Simon Lusignan & Stavros Petrou, 2023. "Symptomatic SARS-CoV-2 Episodes and Health-Related Quality of Life," Applied Health Economics and Health Policy, Springer, vol. 21(5), pages 761-771, September.
    12. Shubhadeep Roychoudhury & Anandan Das & Pallav Sengupta & Sulagna Dutta & Shatabhisha Roychoudhury & Arun Paul Choudhury & A. B. Fuzayel Ahmed & Saumendra Bhattacharjee & Petr Slama, 2020. "Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives," IJERPH, MDPI, vol. 17(24), pages 1-39, December.
    13. Marysia Wrona & Damian Skrypnik, 2022. "New-Onset Diabetes Mellitus, Hypertension, Dyslipidaemia as Sequelae of COVID-19 Infection—Systematic Review," IJERPH, MDPI, vol. 19(20), pages 1-10, October.
    14. Fabian Zech & Daniel Schniertshauer & Christoph Jung & Alexandra Herrmann & Arne Cordsmeier & Qinya Xie & Rayhane Nchioua & Caterina Prelli Bozzo & Meta Volcic & Lennart Koepke & Janis A. Müller & Jan, 2021. "Spike residue 403 affects binding of coronavirus spikes to human ACE2," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    15. Nagla A. El-Shitany & Manal El-Hamamsy & Ahlam A. Alahmadi & Basma G. Eid & Thikryat Neamatallah & Haifa S. Almukadi & Rana A. Arab & Khadija A. Faddladdeen & Khayria A. Al-Sulami & Safia M. Bahshwan , 2021. "The Impact of ABO Blood Grouping on COVID-19 Vulnerability and Seriousness: A Retrospective Cross-Sectional Controlled Study among the Arab Community," IJERPH, MDPI, vol. 18(1), pages 1-19, January.
    16. Ma’ayan Israeli & Yaara Finkel & Yfat Yahalom-Ronen & Nir Paran & Theodor Chitlaru & Ofir Israeli & Inbar Cohen-Gihon & Moshe Aftalion & Reut Falach & Shahar Rotem & Uri Elia & Ital Nemet & Limor Klik, 2022. "Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    17. Carol Nash, 2020. "Report on Digital Literacy in Academic Meetings during the 2020 COVID-19 Lockdown," Challenges, MDPI, vol. 11(2), pages 1-24, September.
    18. Matthew Whitaker & Joshua Elliott & Barbara Bodinier & Wendy Barclay & Helen Ward & Graham Cooke & Christl A. Donnelly & Marc Chadeau-Hyam & Paul Elliott, 2022. "Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    19. Abbasi-Kangevari, Mohsen & Ghanbari, Ali & Malekpour, Mohammad-Reza & Ghamari, Seyyed-Hadi & Azadnajafabad, Sina & Saeedi Moghaddam, Sahar & Keykhaei, Mohammad & Haghshenas, Rosa & Golestani, Ali & Ra, 2023. "Exploring the clinical benefit of ventilation therapy across various patient groups with COVID-19 using real-world data," Open Access Publications from Kiel Institute for the World Economy 273506, Kiel Institute for the World Economy (IfW Kiel).
    20. Charulata Jindal & Sandeep Kumar & Sunil Sharma & Yuk Ming Choi & Jimmy T. Efird, 2020. "The Prevention and Management of COVID-19: Seeking a Practical and Timely Solution," IJERPH, MDPI, vol. 17(11), pages 1-11, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:12011-:d:680156. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.