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Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Author

Listed:
  • Matthew Whitaker

    (Imperial College London
    Imperial College London)

  • Joshua Elliott

    (Imperial College Healthcare NHS Trust
    Imperial College London)

  • Barbara Bodinier

    (Imperial College London
    Imperial College London)

  • Wendy Barclay

    (Imperial College London)

  • Helen Ward

    (Imperial College Healthcare NHS Trust
    Imperial College London
    National Institute for Health Research Imperial Biomedical Research Centre)

  • Graham Cooke

    (Imperial College Healthcare NHS Trust
    Imperial College London
    National Institute for Health Research Imperial Biomedical Research Centre)

  • Christl A. Donnelly

    (Imperial College London
    Imperial College London
    University of Oxford)

  • Marc Chadeau-Hyam

    (Imperial College London
    Imperial College London)

  • Paul Elliott

    (Imperial College London
    Imperial College London
    Imperial College Healthcare NHS Trust
    National Institute for Health Research Imperial Biomedical Research Centre)

Abstract

Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission −1 (REACT-1) study monitored the spread and clinical manifestation of SARS-CoV-2 among random samples of the population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles associated with the different variants over that period, with lower reporting of loss of sense of smell or taste for Omicron compared to previous variants, and higher reporting of cold-like and influenza-like symptoms, controlling for vaccination status. Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities, than BA.1. With restrictions lifted and routine testing limited in many countries, monitoring the changing symptom profiles associated with SARS-CoV-2 infection and effects on daily activities will become increasingly important.

Suggested Citation

  • Matthew Whitaker & Joshua Elliott & Barbara Bodinier & Wendy Barclay & Helen Ward & Graham Cooke & Christl A. Donnelly & Marc Chadeau-Hyam & Paul Elliott, 2022. "Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34244-2
    DOI: 10.1038/s41467-022-34244-2
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    References listed on IDEAS

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    1. Oliver Eales & Leonardo Oliveira Martins & Andrew J. Page & Haowei Wang & Barbara Bodinier & David Tang & David Haw & Jakob Jonnerby & Christina Atchison & Deborah Ashby & Wendy Barclay & Graham Taylo, 2022. "Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Michael C Grant & Luke Geoghegan & Marc Arbyn & Zakaria Mohammed & Luke McGuinness & Emily L Clarke & Ryckie G Wade, 2020. "The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-19, June.
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