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Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Author

Listed:
  • Neeranuch Suwannarin

    (Ph.D. Degree Program in Environmental Science, Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
    Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Tippawan Prapamontol

    (Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Tomohiko Isobe

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Yukiko Nishihama

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Ampica Mangklabruks

    (Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Tawiwan Pantasri

    (Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Somporn Chantara

    (Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Warangkana Naksen

    (Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Shoji F. Nakayama

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

Abstract

Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

Suggested Citation

  • Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(20), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10849-:d:657287
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    References listed on IDEAS

    as
    1. Alyson N. Lorenz & Tippawan Prapamontol & Warangkana Narksen & Niphan Srinual & Dana B. Barr & Anne M. Riederer, 2012. "Pilot Study of Pesticide Knowledge, Attitudes, and Practices among Pregnant Women in Northern Thailand," IJERPH, MDPI, vol. 9(9), pages 1-19, September.
    2. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.
    3. Pornpimol Kongtip & Benyachalee Techasaensiri & Noppanun Nankongnab & Jane Adams & Akkarat Phamonphon & Anu Surach & Supha Sangprasert & Aree Thongsuksai & Prayoon Srikumpol & Susan Woskie, 2017. "The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment," IJERPH, MDPI, vol. 14(6), pages 1-12, May.
    4. Christina Gillezeau & Naomi Alpert & Priyanka Joshi & Emanuela Taioli, 2019. "Urinary Dialkylphosphate Metabolite Levels in US Adults—National Health and Nutrition Examination Survey 1999–2008," IJERPH, MDPI, vol. 16(23), pages 1-10, November.
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    6. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Yuki Hashimoto & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(11), pages 1-16, May.
    7. Matome M. Sekhotha & Kotsedi D. Monyeki & Masezi E. Sibuyi, 2016. "Exposure to Agrochemicals and Cardiovascular Disease: A Review," IJERPH, MDPI, vol. 13(2), pages 1-12, February.
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