IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i10p5190-d554006.html
   My bibliography  Save this article

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Author

Listed:
  • Judit Biosca-Brull

    (Department of Psychology, Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Research in Neurobehavior, Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain)

  • Cristian Pérez-Fernández

    (Department of Psychology, Health Research Center (CEINSA), Almeria University, 04120 Almeria, Spain)

  • Santiago Mora

    (Department of Psychology, Health Research Center (CEINSA), Almeria University, 04120 Almeria, Spain)

  • Beatriz Carrillo

    (Department of Psychobiology, University Institute of Research-UNED-Institute of Health Carlos III (IMIENS), National Distance Education University (UNED), 28015 Madrid, Spain)

  • Helena Pinos

    (Department of Psychobiology, University Institute of Research-UNED-Institute of Health Carlos III (IMIENS), National Distance Education University (UNED), 28015 Madrid, Spain)

  • Nelida Maria Conejo

    (Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, 33011 Oviedo, Spain)

  • Paloma Collado

    (Department of Psychobiology, University Institute of Research-UNED-Institute of Health Carlos III (IMIENS), National Distance Education University (UNED), 28015 Madrid, Spain)

  • Jorge L. Arias

    (Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, 33011 Oviedo, Spain)

  • Fernando Martín-Sánchez

    (National Scholl of Public Health, Institute of Health Carlos III, University Institute of Research-UNED-Institute of Health Carlos III (IMIENS), 28029 Madrid, Spain)

  • Fernando Sánchez-Santed

    (Department of Psychology, Health Research Center (CEINSA), Almeria University, 04120 Almeria, Spain)

  • Maria Teresa Colomina

    (Department of Psychology, Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Research in Neurobehavior, Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain)

Abstract

Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.

Suggested Citation

  • Judit Biosca-Brull & Cristian Pérez-Fernández & Santiago Mora & Beatriz Carrillo & Helena Pinos & Nelida Maria Conejo & Paloma Collado & Jorge L. Arias & Fernando Martín-Sánchez & Fernando Sánchez-San, 2021. "Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models," IJERPH, MDPI, vol. 18(10), pages 1-30, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5190-:d:554006
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/10/5190/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/10/5190/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Pornpimol Kongtip & Benyachalee Techasaensiri & Noppanun Nankongnab & Jane Adams & Akkarat Phamonphon & Anu Surach & Supha Sangprasert & Aree Thongsuksai & Prayoon Srikumpol & Susan Woskie, 2017. "The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment," IJERPH, MDPI, vol. 14(6), pages 1-12, May.
    2. Cheng-Chih Kao & Danielle E. Que & Sayre J. Bongo & Lemmuel L. Tayo & Yi-Hsien Lin & Chun-Wen Lin & Sheng-Lun Lin & Yan-You Gou & Wen-Li Hsu & Cherng-Gueih Shy & Kuo-Lin Huang & Ming-Hsien Tsai & How-, 2019. "Residue Levels of Organochlorine Pesticides in Breast Milk and Its Associations with Cord Blood Thyroid Hormones and the Offspring’s Neurodevelopment," IJERPH, MDPI, vol. 16(8), pages 1-19, April.
    3. Fadi Thabtah & David Peebles, 2019. "Early Autism Screening: A Comprehensive Review," IJERPH, MDPI, vol. 16(18), pages 1-28, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alessandro Miani & Giovanni Imbriani & Giovanni De Filippis & Donato De Giorgi & Luigi Peccarisi & Manuela Colangelo & Manuela Pulimeno & Maria Domenica Castellone & Giuseppe Nicolardi & Giancarlo Log, 2021. "Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Review," IJERPH, MDPI, vol. 18(20), pages 1-15, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ming-Hsien Tsai & How-Ran Chao & Wen-Li Hsu & Ching-Chung Tsai & Chu-Wen Lin & Chu-Huang Chen, 2021. "Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment," IJERPH, MDPI, vol. 18(21), pages 1-18, November.
    2. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.
    3. Simon Chang & Kamhon Kan, 2023. "Do good carefully: The long‐term effects of low‐dose DDT exposure in early childhood on education, marriage and employment," Health Economics, John Wiley & Sons, Ltd., vol. 32(4), pages 807-821, April.
    4. Michał T. Tomczak & Joanna Maria Szulc & Małgorzata Szczerska, 2021. "Inclusive Communication Model Supporting the Employment Cycle of Individuals with Autism Spectrum Disorders," IJERPH, MDPI, vol. 18(9), pages 1-12, April.
    5. Bijan Mehralizadeh & Bahar Baradaran & Shahab Nikkhoo & Pegah Soleiman & Hadi Moradi, 2023. "A Sensorized Toy Car for Autism Screening Using Multi-Modal Features," Sustainability, MDPI, vol. 15(10), pages 1-10, May.
    6. Maya Hayden-Evans & Benjamin Milbourn & Emily D’Arcy & Angela Chamberlain & Bahareh Afsharnejad & Kiah Evans & Andrew J. O. Whitehouse & Sven Bölte & Sonya Girdler, 2022. "An Evaluation of the Overall Utility of Measures of Functioning Suitable for School-Aged Children on the Autism Spectrum: A Scoping Review," IJERPH, MDPI, vol. 19(21), pages 1-29, October.
    7. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(20), pages 1-14, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5190-:d:554006. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.