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The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment

Author

Listed:
  • Pornpimol Kongtip

    (Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand)

  • Benyachalee Techasaensiri

    (Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand)

  • Noppanun Nankongnab

    (Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand)

  • Jane Adams

    (Department of Psychology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA)

  • Akkarat Phamonphon

    (Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand)

  • Anu Surach

    (Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand)

  • Supha Sangprasert

    (Sawanpracharak Hospital, 43 Autakavee Road, Paknumpo, Muang, Nakhon Sawan 60000, Thailand)

  • Aree Thongsuksai

    (Paholpolpayuhasena Hospital, 572 Sangchuto Road, Ban Tai, Kanchanaburi 71000, Thailand)

  • Prayoon Srikumpol

    (Amnatcharoen Hospital, 291 Arunprasert Road, Muang, Amnatcharoen 37000, Thailand)

  • Susan Woskie

    (College of Health Sciences, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854-2867, USA)

Abstract

A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures. Spot urine samples were collected at 28 weeks gestation and analyzed by gas chromatography-mass spectrometry to determine maternal metabolite levels of organophosphate pesticides including dimethyl phosphate (DMP); total DEP (diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), and total DAP (the sum of all metabolite levels). At five months of age, infant development was evaluated using the Bayley Scales of Infant and Toddler Development-III (Bayley-III). Higher total DEP and total DAP metabolite levels from the mother at 28 weeks’ gestation were significantly associated with reduced motor composite scores on the Bayley-III at five months of age. The total DEP levels were also significantly associated with reduced cognitive composite scores. Prenatal concentrations of maternal urinary metabolites were associated with infant cognitive and motor development. The results of several studies now suggest the need for public health intervention to reduce prenatal pesticide exposures from both agricultural and domestic use.

Suggested Citation

  • Pornpimol Kongtip & Benyachalee Techasaensiri & Noppanun Nankongnab & Jane Adams & Akkarat Phamonphon & Anu Surach & Supha Sangprasert & Aree Thongsuksai & Prayoon Srikumpol & Susan Woskie, 2017. "The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment," IJERPH, MDPI, vol. 14(6), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:570-:d:99826
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    Citations

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    Cited by:

    1. Judit Biosca-Brull & Cristian Pérez-Fernández & Santiago Mora & Beatriz Carrillo & Helena Pinos & Nelida Maria Conejo & Paloma Collado & Jorge L. Arias & Fernando Martín-Sánchez & Fernando Sánchez-San, 2021. "Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models," IJERPH, MDPI, vol. 18(10), pages 1-30, May.
    2. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(20), pages 1-14, October.
    3. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.

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