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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

Author

Listed:
  • V. Stalin Raj

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Huihui Mou

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Saskia L. Smits

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Viroclinics Biosciences BV, 3029 AK Rotterdam, The Netherlands)

  • Dick H. W. Dekkers

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Marcel A. Müller

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Ronald Dijkman

    (Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland)

  • Doreen Muth

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Jeroen A. A. Demmers

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Ali Zaki

    (Virology Laboratory, Dr Soliman Fakeeh Hospital)

  • Ron A. M. Fouchier

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Volker Thiel

    (Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland)

  • Christian Drosten

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Peter J. M. Rottier

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Albert D. M. E. Osterhaus

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Berend Jan Bosch

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Bart L. Haagmans

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

Abstract

Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.

Suggested Citation

  • V. Stalin Raj & Huihui Mou & Saskia L. Smits & Dick H. W. Dekkers & Marcel A. Müller & Ronald Dijkman & Doreen Muth & Jeroen A. A. Demmers & Ali Zaki & Ron A. M. Fouchier & Volker Thiel & Christian Dr, 2013. "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC," Nature, Nature, vol. 495(7440), pages 251-254, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature12005
    DOI: 10.1038/nature12005
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    Cited by:

    1. Yan Yang & Zixin Cai & Jingjing Zhang, 2021. "DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-10, May.
    2. Mohamed A. Farrag & Haitham M. Amer & Rauf Bhat & Maaweya E. Hamed & Ibrahim M. Aziz & Ayman Mubarak & Turki M Dawoud & Sami G Almalki & Fayez Alghofaili & Ahmad K. Alnemare & Raid Saleem Al-Baradi & , 2021. "SARS-CoV-2: An Overview of Virus Genetics, Transmission, and Immunopathogenesis," IJERPH, MDPI, vol. 18(12), pages 1-14, June.
    3. Milad Haghani & Pegah Varamini, 2021. "Temporal evolution, most influential studies and sleeping beauties of the coronavirus literature," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 7005-7050, August.
    4. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Hossein Hozhabri & Francesca Piceci Sparascio & Hamidreza Sohrabi & Leila Mousavifar & René Roy & Daniela Scribano & Alessandro De Luca & Cecilia Ambrosi & Meysam Sarshar, 2020. "The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting," IJERPH, MDPI, vol. 17(16), pages 1-35, August.
    6. Muhammad Azher Hassan & Tariq Mehmood & Ehtisham Lodhi & Muhammad Bilal & Afzal Ahmed Dar & Junjie Liu, 2022. "Lockdown Amid COVID-19 Ascendancy over Ambient Particulate Matter Pollution Anomaly," IJERPH, MDPI, vol. 19(20), pages 1-31, October.
    7. Chunyan Wang & Emma L. Hesketh & Tatiana M. Shamorkina & Wentao Li & Peter J. Franken & Dubravka Drabek & Rien Haperen & Sarah Townend & Frank J. M. Kuppeveld & Frank Grosveld & Neil A. Ranson & Joost, 2022. "Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. Weiwei Ji & Qi Peng & Xueqiong Fang & Zehou Li & Yaxin Li & Cunfa Xu & Shuqing Zhao & Jizong Li & Rong Chen & Guoxiang Mo & Zhanyong Wei & Ying Xu & Bin Li & Shuijun Zhang, 2022. "Structures of a deltacoronavirus spike protein bound to porcine and human receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Tuersunjiang Keyoumu & Wanbiao Ma & Ke Guo, 2023. "Global Stability of a MERS-CoV Infection Model with CTL Immune Response and Intracellular Delay," Mathematics, MDPI, vol. 11(4), pages 1-26, February.
    10. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    11. Shubhadeep Roychoudhury & Anandan Das & Pallav Sengupta & Sulagna Dutta & Shatabhisha Roychoudhury & Arun Paul Choudhury & A. B. Fuzayel Ahmed & Saumendra Bhattacharjee & Petr Slama, 2020. "Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives," IJERPH, MDPI, vol. 17(24), pages 1-39, December.
    12. Maria Mirabelli & Eusebio Chiefari & Luigi Puccio & Daniela Patrizia Foti & Antonio Brunetti, 2020. "Potential Benefits and Harms of Novel Antidiabetic Drugs During COVID-19 Crisis," IJERPH, MDPI, vol. 17(10), pages 1-12, May.

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