IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v339y2004i3p531-547.html
   My bibliography  Save this article

A model of morphogenesis

Author

Listed:
  • Cummings, F.W

Abstract

A new model is presented of a patterning mechanism in animals. It is argued that the ‘Wnt’ signaling pathway often acts in binary conjunction with a variety of other pathways to produce complex patterning. This patterning follows while involving little of the detailed biochemistry of either of the two pathways involved. The patterns arise spontaneously from a state of zero pattern activation upon achieving a specified (epithelial) sphere radius. Gastrulation follows from the simplest solution, and assuming a simplest form for the coupling of the Gauss and Mean curvatures to the morphogens. Numerical solutions are presented, and predictions of the model are discussed.

Suggested Citation

  • Cummings, F.W, 2004. "A model of morphogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 339(3), pages 531-547.
    • Handle: RePEc:eee:phsmap:v:339:y:2004:i:3:p:531-547
    DOI: 10.1016/j.physa.2004.04.047
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437104004558
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000
    File URL: https://libkey.io/10.1016/j.physa.2004.04.047?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Karl Willert & Jeffrey D. Brown & Esther Danenberg & Andrew W. Duncan & Irving L. Weissman & Tannishtha Reya & John R. Yates & Roel Nusse, 2003. "Wnt proteins are lipid-modified and can act as stem cell growth factors," Nature, Nature, vol. 423(6938), pages 448-452, May.
    2. J. B. Gurdon & P.-Y. Bourillot, 2001. "Morphogen gradient interpretation," Nature, Nature, vol. 413(6858), pages 797-803, October.
    3. Sandrine Etienne-Manneville & Alan Hall, 2002. "Rho GTPases in cell biology," Nature, Nature, vol. 420(6916), pages 629-635, December.
    4. Colin Jamora & Ramanuj DasGupta & Pawel Kocieniewski & Elaine Fuchs, 2003. "Erratum: Links between signal transduction, transcription and adhesion in epithelial bud development," Nature, Nature, vol. 424(6951), pages 974-974, August.
    5. Osamu Tetsu & Frank McCormick, 1999. "β-Catenin regulates expression of cyclin D1 in colon carcinoma cells," Nature, Nature, vol. 398(6726), pages 422-426, April.
    6. Jussi Taipale & Philip A. Beachy, 2001. "The Hedgehog and Wnt signalling pathways in cancer," Nature, Nature, vol. 411(6835), pages 349-354, May.
    7. Christof Niehrs, 2001. "Solving a sticky problem," Nature, Nature, vol. 413(6858), pages 787-788, October.
    8. Athula H. Wikramanayake & Melanie Hong & Patricia N. Lee & Kevin Pang & Christine A. Byrum & Joanna M. Bince & Ronghui Xu & Mark Q. Martindale, 2003. "An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation," Nature, Nature, vol. 426(6965), pages 446-450, November.
    9. Colin Jamora & Ramanuj DasGupta & Pawel Kocieniewski & Elaine Fuchs, 2003. "Links between signal transduction, transcription and adhesion in epithelial bud development," Nature, Nature, vol. 422(6929), pages 317-322, March.
    10. Olga Speck & Sarah C. Hughes & Nicole K. Noren & Rima M. Kulikauskas & Richard G. Fehon, 2003. "Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity," Nature, Nature, vol. 421(6918), pages 83-87, January.
    11. George von Dassow & Eli Meir & Edwin M. Munro & Garrett M. Odell, 2000. "The segment polarity network is a robust developmental module," Nature, Nature, vol. 406(6792), pages 188-192, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Cummings, F.W., 2005. "Interaction of morphogens with geometry," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 355(2), pages 427-438.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Valeria Sibilia & Daniele Bottai & Roberto Maggi & Francesca Pagani & Raffaella Chiaramonte & Domenica Giannandrea & Valentina Citro & Natalia Platonova & Lavinia Casati, 2021. "Sex Steroid Regulation of Oxidative Stress in Bone Cells: An In Vitro Study," IJERPH, MDPI, vol. 18(22), pages 1-23, November.
    2. Limei Wu & Srinivas Chatla & Qiqi Lin & Fabliha Ahmed Chowdhury & Werner Geldenhuys & Wei Du, 2021. "Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Gabriela Casanova-Sepúlveda & Joel A. Sexton & Benjamin E. Turk & Titus J. Boggon, 2023. "Autoregulation of the LIM kinases by their PDZ domain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Rashmi Priya & Guillermo A Gomez & Srikanth Budnar & Bipul R Acharya & Andras Czirok & Alpha S Yap & Zoltan Neufeld, 2017. "Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions," PLOS Computational Biology, Public Library of Science, vol. 13(3), pages 1-19, March.
    5. Cezanne Miete & Gonzalo P. Solis & Alexey Koval & Martina Brückner & Vladimir L. Katanaev & Jürgen Behrens & Dominic B. Bernkopf, 2022. "Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Mariel C. Paul & Christian Schneeweis & Chiara Falcomatà & Chuan Shan & Daniel Rossmeisl & Stella Koutsouli & Christine Klement & Magdalena Zukowska & Sebastian A. Widholz & Moritz Jesinghaus & Konsta, 2023. "Non-canonical functions of SNAIL drive context-specific cancer progression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    7. Juan Manuel Ortiz-Sanchez & Sara E Nichols & Jacqueline Sayyah & Joan Heller Brown & J Andrew McCammon & Barry J Grant, 2012. "Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-13, July.
    8. Manuel Cambón & Óscar Sánchez, 2022. "Thermodynamic Modelling of Transcriptional Control: A Sensitivity Analysis," Mathematics, MDPI, vol. 10(13), pages 1-18, June.
    9. Guillaume Serwe & David Kachaner & Jessica Gagnon & Cédric Plutoni & Driss Lajoie & Eloïse Duramé & Malha Sahmi & Damien Garrido & Martin Lefrançois & Geneviève Arseneault & Marc K. Saba-El-Leil & Syl, 2023. "CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    10. Debasish Mondal & Edward Dougherty & Abhishek Mukhopadhyay & Adria Carbo & Guang Yao & Jianhua Xing, 2014. "Systematic Reverse Engineering of Network Topologies: A Case Study of Resettable Bistable Cellular Responses," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-12, August.
    11. Luís António Menezes Carreira & Dobromir Szadkowski & Stefano Lometto & Georg. K. A. Hochberg & Lotte Søgaard-Andersen, 2023. "Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    12. Guillermo Rodrigo & Santiago F Elena, 2011. "Structural Discrimination of Robustness in Transcriptional Feedforward Loops for Pattern Formation," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    13. Joachim Hanna & Flavio Beke & Louise M. O’Brien & Chrysa Kapeni & Hung-Chang Chen & Valentina Carbonaro & Alexander B. Kim & Kamal Kishore & Timon E. Adolph & Mikkel-Ole Skjoedt & Karsten Skjoedt & Ma, 2022. "Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    14. Carl Song & Hilary Phenix & Vida Abedi & Matthew Scott & Brian P Ingalls & Mads Kærn & Theodore J Perkins, 2010. "Estimating the Stochastic Bifurcation Structure of Cellular Networks," PLOS Computational Biology, Public Library of Science, vol. 6(3), pages 1-11, March.
    15. Grant Ongo & Sébastien G Ricoult & Timothy E Kennedy & David Juncker, 2014. "Ordered, Random, Monotonic and Non-Monotonic Digital Nanodot Gradients," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    16. Jocelyn E. Chau & Kimberly J. Vish & Titus J. Boggon & Amy L. Stiegler, 2022. "SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    17. Adel Dayarian & Madalena Chaves & Eduardo D Sontag & Anirvan M Sengupta, 2009. "Shape, Size, and Robustness: Feasible Regions in the Parameter Space of Biochemical Networks," PLOS Computational Biology, Public Library of Science, vol. 5(1), pages 1-12, January.
    18. Gaetane Nocturne & Stephan Pavy & Saida Boudaoud & Raphaèle Seror & Philippe Goupille & Philippe Chanson & Désirée van der Heijde & Floris van Gaalen & Francis Berenbaum & Xavier Mariette & Karine Bri, 2015. "Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    19. Benjamin L. Walker & Qing Nie, 2023. "NeST: nested hierarchical structure identification in spatial transcriptomic data," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    20. Steffen Nørgaard & Shuer Deng & Wei Cao & Roger Pocock, 2018. "Distinct CED-10/Rac1 domains confer context-specific functions in development," PLOS Genetics, Public Library of Science, vol. 14(9), pages 1-24, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:339:y:2004:i:3:p:531-547. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.