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Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity

Author

Listed:
  • Olga Speck

    (Duke University
    University of North Carolina)

  • Sarah C. Hughes

    (Duke University
    University of North Carolina)

  • Nicole K. Noren

    (University of North Carolina)

  • Rima M. Kulikauskas

    (Duke University
    University of North Carolina)

  • Richard G. Fehon

    (Duke University
    University of North Carolina)

Abstract

Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized protein complexes associated with the apical plasma membrane1,2, and on a separate machinery that regulates the spatial order of actin assembly3. ERM (ezrin, radixin, moesin) proteins have been proposed to link transmembrane proteins to the actin cytoskeleton4 in the apical domain, suggesting a structural role in epithelial cells, and they have been implicated in signalling pathways5. Here, we show that the sole Drosophila ERM protein Moesin functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking Moesin lose epithelial characteristics and adopt invasive migratory behaviour. Our data demonstrate that Moesin facilitates epithelial morphology not by providing an essential structural function, but rather by antagonizing activity of the small GTPase Rho. Thus, Moesin functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin organization and polarity. Furthermore, our results show that there is negative feedback between ERM activation and activity of the Rho pathway.

Suggested Citation

  • Olga Speck & Sarah C. Hughes & Nicole K. Noren & Rima M. Kulikauskas & Richard G. Fehon, 2003. "Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity," Nature, Nature, vol. 421(6918), pages 83-87, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6918:d:10.1038_nature01295
    DOI: 10.1038/nature01295
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    Cited by:

    1. Kazuya Tsujita & Reiko Satow & Shinobu Asada & Yoshikazu Nakamura & Luis Arnes & Keisuke Sako & Yasuyuki Fujita & Kiyoko Fukami & Toshiki Itoh, 2021. "Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Cummings, F.W, 2004. "A model of morphogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 339(3), pages 531-547.

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