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Dynamics of leprosy in nine-banded armadillos: Net reproductive number and effects on host population dynamics

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  • Oli, Madan K.
  • Loughry, W.J.
  • Caswell, Hal
  • Perez-Heydrich, Carolina
  • McDonough, Colleen M.
  • Truman, Richard W.

Abstract

Leprosy (or Hansen’s disease) remains an important public health challenge globally, with an estimated 5.5 million total number of cases and 200,000–300,000 new cases reported annually. The nine-banded armadillo (Dasypus novemcinctus) is the only known natural non-human vertebrate host of Mycobacterium leprae, the causative agent of leprosy, in the Americas, yet gaps in knowledge remain regarding the dynamics of leprosy in wild populations. Here, we used data from a six-year study of a population of armadillos in Mississippi, USA to quantify the influence of leprosy on armadillo population dynamics, and to investigate leprosy dynamics within the host population. Leprosy reduced annual survival of adult armadillos by ∼15%, and growth rate of the population by ∼13%. The annual infection rate for adult armadillos (i.e., probability that a non-leprous adult armadillo seroconverts, conditional on survival) was 0.18, with no possibility of recovery. Assuming frequency-dependent transmission of leprosy, 18% to 25% of the adult armadillos will acquire leprosy infection in the long run. Finally, the basic reproductive ratio (R0) was 1.36, suggesting 36% increase in seroprevalence per leprosy generation. Assuming that leprosy generation time is 3–5 years, M. leprae will spread within the armadillo population at the rate of 7–12% per year. Our results are consistent with recent evidence that leprosy infection in armadillos in the USA is spreading rapidly with a concomitant increase in risk for zoonotic transmissions.

Suggested Citation

  • Oli, Madan K. & Loughry, W.J. & Caswell, Hal & Perez-Heydrich, Carolina & McDonough, Colleen M. & Truman, Richard W., 2017. "Dynamics of leprosy in nine-banded armadillos: Net reproductive number and effects on host population dynamics," Ecological Modelling, Elsevier, vol. 350(C), pages 100-108.
    • Handle: RePEc:eee:ecomod:v:350:y:2017:i:c:p:100-108
    DOI: 10.1016/j.ecolmodel.2017.02.001
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    1. J. Alan Pounds & Martín R. Bustamante & Luis A. Coloma & Jamie A. Consuegra & Michael P. L. Fogden & Pru N. Foster & Enrique La Marca & Karen L. Masters & Andrés Merino-Viteri & Robert Puschendorf & S, 2006. "Widespread amphibian extinctions from epidemic disease driven by global warming," Nature, Nature, vol. 439(7073), pages 161-167, January.
    2. Hal Caswell, 2008. "Perturbation analysis of nonlinear matrix population models," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 18(3), pages 59-116.
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    1. Patrícia Deps & João Marcelo Antunes & Adalberto Rezende Santos & Simon M Collin, 2020. "Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(3), pages 1-16, March.

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