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A mixture of logistic skew-normal multinomial models

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  • Tu, Wangshu
  • Browne, Ryan
  • Subedi, Sanjeena

Abstract

The logistic normal multinomial distribution is gaining interest in modelling microbiome data. It utilizes a hierarchical structure such that the observed counts conditional on the compositions are assumed to be multinomial random variables and the log-ratio transformed compositions are assumed to be from a Gaussian distribution. While multinomial distribution accounts for the compositional nature of the data, and a Gaussian prior offers flexibility in the structure of covariance matrices, the log-ratio transformed compositions of the microbiome data can be highly skewed, especially at a lower taxonomic level. Thus, a Gaussian distribution may not be an ideal prior for the log-ratio transformed compositions. A novel mixture of logistic skew-normal multinomial (LSNM) distribution is proposed in which a multivariate skew-normal distribution is utilized as a prior for the log-ratio transformed compositions. A variational Gaussian approximation in conjunction with the EM algorithm is utilized for parameter estimation.

Suggested Citation

  • Tu, Wangshu & Browne, Ryan & Subedi, Sanjeena, 2024. "A mixture of logistic skew-normal multinomial models," Computational Statistics & Data Analysis, Elsevier, vol. 196(C).
    • Handle: RePEc:eee:csdana:v:196:y:2024:i:c:s0167947324000306
    DOI: 10.1016/j.csda.2024.107946
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