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Gut mucosal microbiome across stages of colorectal carcinogenesis

Author

Listed:
  • Geicho Nakatsu

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Xiangchun Li

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Haokui Zhou

    (The Chinese University of Hong Kong)

  • Jianqiu Sheng

    (Beijing Military General Hospital)

  • Sunny Hei Wong

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • William Ka Kai Wu

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute
    The Chinese University of Hong Kong)

  • Siew Chien Ng

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Ho Tsoi

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Yujuan Dong

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Ning Zhang

    (The First Affiliated Hospital of Sun Yat-sen University)

  • Yuqi He

    (Beijing Military General Hospital)

  • Qian Kang

    (Beijing Military General Hospital)

  • Lei Cao

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Kunning Wang

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Jingwan Zhang

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Qiaoyi Liang

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Jun Yu

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

  • Joseph J. Y. Sung

    (Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
    CUHK Shenzhen Research Institute)

Abstract

Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.

Suggested Citation

  • Geicho Nakatsu & Xiangchun Li & Haokui Zhou & Jianqiu Sheng & Sunny Hei Wong & William Ka Kai Wu & Siew Chien Ng & Ho Tsoi & Yujuan Dong & Ning Zhang & Yuqi He & Qian Kang & Lei Cao & Kunning Wang & J, 2015. "Gut mucosal microbiome across stages of colorectal carcinogenesis," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9727
    DOI: 10.1038/ncomms9727
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    Cited by:

    1. Efrat Muller & Itamar Shiryan & Elhanan Borenstein, 2024. "Multi-omic integration of microbiome data for identifying disease-associated modules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yongzhi Yang & Lutao Du & Debing Shi & Cheng Kong & Jianqiang Liu & Guang Liu & Xinxiang Li & Yanlei Ma, 2021. "Dysbiosis of human gut microbiome in young-onset colorectal cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Sanjeena Subedi & Drew Neish & Stephen Bak & Zeny Feng, 2020. "Cluster analysis of microbiome data by using mixtures of Dirichlet–multinomial regression models," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 69(5), pages 1163-1187, November.
    4. Tu, Wangshu & Browne, Ryan & Subedi, Sanjeena, 2024. "A mixture of logistic skew-normal multinomial models," Computational Statistics & Data Analysis, Elsevier, vol. 196(C).

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