IDEAS home Printed from https://ideas.repec.org/a/bla/biomet/v79y2023i2p695-710.html
   My bibliography  Save this article

Semiparametric additive time‐varying coefficients model for longitudinal data with censored time origin

Author

Listed:
  • Yanqing Sun
  • Qiong Shou
  • Peter B. Gilbert
  • Fei Heng
  • Xiyuan Qian

Abstract

Statistical analysis of longitudinal data often involves modeling treatment effects on clinically relevant longitudinal biomarkers since an initial event (the time origin). In some studies including preventive HIV vaccine efficacy trials, some participants have biomarkers measured starting at the time origin, whereas others have biomarkers measured starting later with the time origin unknown. The semiparametric additive time‐varying coefficient model is investigated where the effects of some covariates vary nonparametrically with time while the effects of others remain constant. Weighted profile least squares estimators coupled with kernel smoothing are developed. The method uses the expectation maximization approach to deal with the censored time origin. The Kaplan–Meier estimator and other failure time regression models such as the Cox model can be utilized to estimate the distribution and the conditional distribution of left censored event time related to the censored time origin. Asymptotic properties of the parametric and nonparametric estimators and consistent asymptotic variance estimators are derived. A two‐stage estimation procedure for choosing weight is proposed to improve estimation efficiency. Numerical simulations are conducted to examine finite sample properties of the proposed estimators. The simulation results show that the theory and methods work well. The efficiency gain of the two‐stage estimation procedure depends on the distribution of the longitudinal error processes. The method is applied to analyze data from the Merck 023/HVTN 502 Step HIV vaccine study.

Suggested Citation

  • Yanqing Sun & Qiong Shou & Peter B. Gilbert & Fei Heng & Xiyuan Qian, 2023. "Semiparametric additive time‐varying coefficients model for longitudinal data with censored time origin," Biometrics, The International Biometric Society, vol. 79(2), pages 695-710, June.
    • Handle: RePEc:bla:biomet:v:79:y:2023:i:2:p:695-710
    DOI: 10.1111/biom.13610
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/biom.13610
    Download Restriction: no
    File URL: https://libkey.io/10.1111/biom.13610?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bryan E. Shepherd & Peter B. Gilbert & Yannis Jemiai & Andrea Rotnitzky, 2006. "Sensitivity Analyses Comparing Outcomes Only Existing in a Subset Selected Post-Randomization, Conditional on Covariates, with Application to HIV Vaccine Trials," Biometrics, The International Biometric Society, vol. 62(2), pages 332-342, June.
    2. Yanqing Sun & Peter B. Gilbert, 2012. "Estimation of Stratified Mark‐Specific Proportional Hazards Models with Missing Marks," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 39(1), pages 34-52, March.
    3. Yanqing Sun & Xiyuan Qian & Qiong Shou & Peter B. Gilbert, 2017. "Analysis of two-phase sampling data with semiparametric additive hazards models," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(3), pages 377-399, July.
    4. Li Qi & Yanqing Sun & Peter B. Gilbert, 2017. "Generalized semiparametric varying-coefficient model for longitudinal data with applications to adaptive treatment randomizations," Biometrics, The International Biometric Society, vol. 73(2), pages 441-451, June.
    5. Fan, Jianqing & Huang, Tao & Li, Runze, 2007. "Analysis of Longitudinal Data With Semiparametric Estimation of Covariance Function," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 632-641, June.
    6. Zonghui Hu, 2004. "Profile-kernel versus backfitting in the partially linear models for longitudinal/clustered data," Biometrika, Biometrika Trust, vol. 91(2), pages 251-262, June.
    7. Lin D Y & Ying Z, 2001. "Semiparametric and Nonparametric Regression Analysis of Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 103-126, March.
    8. Lin X. & Carroll R. J., 2001. "Semiparametric Regression for Clustered Data Using Generalized Estimating Equations," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1045-1056, September.
    9. Naisyin Wang & Raymond J. Carroll & Xihong Lin, 2005. "Efficient Semiparametric Marginal Estimation for Longitudinal/Clustered Data," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 147-157, March.
    10. Annie Qu & Runze Li, 2006. "Quadratic Inference Functions for Varying-Coefficient Models with Longitudinal Data," Biometrics, The International Biometric Society, vol. 62(2), pages 379-391, June.
    11. Ying, Zhiliang, 1989. "A note on the asymptotic properties of the product-limit estimator on the whole line," Statistics & Probability Letters, Elsevier, vol. 7(4), pages 311-314, February.
    12. Guangren Yang & Yanqing Sun & Li Qi & Peter B. Gilbert, 2017. "Estimation of Stratified Mark-Specific Proportional Hazards Models Under Two-Phase Sampling with Application to HIV Vaccine Efficacy Trials," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(1), pages 259-283, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. M. Taavoni & M. Arashi, 2021. "Kernel estimation in semiparametric mixed effect longitudinal modeling," Statistical Papers, Springer, vol. 62(3), pages 1095-1116, June.
    2. Chen, Huaihou & Paik, Myunghee Cho & Dhamoon, Mandip S. & Moon, Yeseon Park & Willey, Joshua & Sacco, Ralph L. & Elkind, Mitchell S.V., 2012. "Semiparametric model for the dichotomized functional outcome after stroke: The Northern Manhattan Study," Computational Statistics & Data Analysis, Elsevier, vol. 56(8), pages 2598-2608.
    3. Jia Chen & Degui Li & Hua Liang & Suojin Wang, 2014. "Semiparametric GEE Analysis in Partially Linear Single-Index Models for Longitudinal Data," Discussion Papers 14/26, Department of Economics, University of York.
    4. Al Kadiri, M. & Carroll, R.J. & Wand, M.P., 2010. "Marginal longitudinal semiparametric regression via penalized splines," Statistics & Probability Letters, Elsevier, vol. 80(15-16), pages 1242-1252, August.
    5. Li, Jialiang & Xia, Yingcun & Palta, Mari & Shankar, Anoop, 2009. "Impact of unknown covariance structures in semiparametric models for longitudinal data: An application to Wisconsin diabetes data," Computational Statistics & Data Analysis, Elsevier, vol. 53(12), pages 4186-4197, October.
    6. Lai, Peng & Li, Gaorong & Lian, Heng, 2013. "Quadratic inference functions for partially linear single-index models with longitudinal data," Journal of Multivariate Analysis, Elsevier, vol. 118(C), pages 115-127.
    7. Chen, Ziqi & Shi, Ning-Zhong & Gao, Wei & Tang, Man-Lai, 2011. "Efficient semiparametric estimation via Cholesky decomposition for longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3344-3354, December.
    8. Henderson, Daniel J. & Carroll, Raymond J. & Li, Qi, 2008. "Nonparametric estimation and testing of fixed effects panel data models," Journal of Econometrics, Elsevier, vol. 144(1), pages 257-275, May.
    9. Jia, Shengji & Zhang, Chunming & Lu, Haoran, 2022. "Covariance function versus covariance matrix estimation in efficient semi-parametric regression for longitudinal data analysis," Journal of Multivariate Analysis, Elsevier, vol. 187(C).
    10. Weihua Zhao & Weiping Zhang & Heng Lian, 2020. "Marginal quantile regression for varying coefficient models with longitudinal data," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 72(1), pages 213-234, February.
    11. Cho, Hyunkeun & Kim, Seonjin, 2017. "Model specification test in a semiparametric regression model for longitudinal data," Journal of Multivariate Analysis, Elsevier, vol. 160(C), pages 105-116.
    12. Hans-Georg Müller & Wenjing Yang, 2010. "Dynamic relations for sparsely sampled Gaussian processes," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 19(1), pages 1-29, May.
    13. Xueying Zheng & Wing Fung & Zhongyi Zhu, 2013. "Robust estimation in joint mean–covariance regression model for longitudinal data," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 65(4), pages 617-638, August.
    14. Zou, Yubo & Zhang, Jiajia & Qin, Guoyou, 2011. "A semiparametric accelerated failure time partial linear model and its application to breast cancer," Computational Statistics & Data Analysis, Elsevier, vol. 55(3), pages 1479-1487, March.
    15. Jia Chen & Degui Li & Yingcun Xia, 2015. "New Semiparametric Estimation Procedure for Functional Coefficient Longitudinal Data Models," Discussion Papers 15/17, Department of Economics, University of York.
    16. Lee, Unkyung & Sun, Yanqing & Scheike, Thomas H. & Gilbert, Peter B., 2018. "Analysis of generalized semiparametric regression models for cumulative incidence functions with missing covariates," Computational Statistics & Data Analysis, Elsevier, vol. 122(C), pages 59-79.
    17. Haibo Zhou & Guoyou Qin & Matthew P. Longnecker, 2011. "A Partial Linear Model in the Outcome-Dependent Sampling Setting to Evaluate the Effect of Prenatal PCB Exposure on Cognitive Function in Children," Biometrics, The International Biometric Society, vol. 67(3), pages 876-885, September.
    18. Tuglus Catherine & van der Laan Mark J., 2011. "Repeated Measures Semiparametric Regression Using Targeted Maximum Likelihood Methodology with Application to Transcription Factor Activity Discovery," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-31, January.
    19. Ziqi Chen & Man†Lai Tang & Wei Gao, 2018. "A profile likelihood approach for longitudinal data analysis," Biometrics, The International Biometric Society, vol. 74(1), pages 220-228, March.
    20. Hamadi, Malika & Heinen, Andréas, 2015. "Firm performance when ownership is very concentrated: Evidence from a semiparametric panel," Journal of Empirical Finance, Elsevier, vol. 34(C), pages 172-194.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:biomet:v:79:y:2023:i:2:p:695-710. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: http://www.blackwellpublishing.com/journal.asp?ref=0006-341X .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.