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Integrated powered density: Screening ultrahigh dimensional covariates with survival outcomes

Author

Listed:
  • Hyokyoung G. Hong
  • Xuerong Chen
  • David C. Christiani
  • Yi Li

Abstract

Modern biomedical studies have yielded abundant survival data with high†throughput predictors. Variable screening is a crucial first step in analyzing such data, for the purpose of identifying predictive biomarkers, understanding biological mechanisms, and making accurate predictions. To nonparametrically quantify the relevance of each candidate variable to the survival outcome, we propose integrated powered density (IPOD), which compares the differences in the covariate†stratified distribution functions. The proposed new class of statistics, with a flexible weighting scheme, is general and includes the Kolmogorov statistic as a special case. Moreover, the method does not rely on rigid regression model assumptions and can be easily implemented. We show that our method possesses sure screening properties, and confirm the utility of the proposal with extensive simulation studies. We apply the method to analyze a multiple myeloma study on detecting gene signatures for cancer patients’ survival.

Suggested Citation

  • Hyokyoung G. Hong & Xuerong Chen & David C. Christiani & Yi Li, 2018. "Integrated powered density: Screening ultrahigh dimensional covariates with survival outcomes," Biometrics, The International Biometric Society, vol. 74(2), pages 421-429, June.
    • Handle: RePEc:bla:biomet:v:74:y:2018:i:2:p:421-429
    DOI: 10.1111/biom.12820
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    References listed on IDEAS

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    Cited by:

    1. Lu, Shuiyun & Chen, Xiaolin & Xu, Sheng & Liu, Chunling, 2020. "Joint model-free feature screening for ultra-high dimensional semi-competing risks data," Computational Statistics & Data Analysis, Elsevier, vol. 147(C).
    2. Grace Y. Yi & Wenqing He & Raymond. J. Carroll, 2022. "Feature screening with large‐scale and high‐dimensional survival data," Biometrics, The International Biometric Society, vol. 78(3), pages 894-907, September.
    3. Qu, Lianqiang & Wang, Xiaoyu & Sun, Liuquan, 2022. "Variable screening for varying coefficient models with ultrahigh-dimensional survival data," Computational Statistics & Data Analysis, Elsevier, vol. 172(C).
    4. Jialiang Li & Tonghui Yu & Jing Lv & Mei‐Ling Ting Lee, 2021. "Semiparametric model averaging prediction for lifetime data via hazards regression," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 70(5), pages 1187-1209, November.
    5. Yang Qu & Yu Cheng, 2023. "Volume under the ROC surface for high-dimensional independent screening with ordinal competing risk outcomes," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(4), pages 735-751, October.
    6. Xiaolin Chen & Catherine Chunling Liu & Sheng Xu, 2021. "An efficient algorithm for joint feature screening in ultrahigh-dimensional Cox’s model," Computational Statistics, Springer, vol. 36(2), pages 885-910, June.
    7. Zhong, Wei & Wang, Jiping & Chen, Xiaolin, 2021. "Censored mean variance sure independence screening for ultrahigh dimensional survival data," Computational Statistics & Data Analysis, Elsevier, vol. 159(C).

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