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Collaboration in pharmaceutical research: Exploration of country-level determinants

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Listed:
  • Tatiana Plotnikova

    (Friedrich-Schiller-University, Jena, Graduate College "The Economics of Innovative Change")

  • Bastian Rake

    (Friedrich-Schiller-University, Jena, Graduate College "The Economics of Innovative Change")

Abstract

In this paper we focus on proximity as one of the main determinants of international collaboration in pharmaceutical research. We use various count data specifications of the gravity model to estimate the intensity of collaboration between pairs of countries as explained by the geographical, cognitive, institutional, social, and cultural dimensions of proximity. Our results suggest that geographical distance has a significant negative relation to the collaboration intensity between countries. The amount of previous collaborations, as a proxy for social proximity, is positively related to the number of cross-country collaborations. We do not find robust significant associations between cognitive proximity or institutional proximity with the intensity of international research collaboration. Moreover, there is no robust and significant relation between the interaction terms of geographical distance with social, cognitive, or institutional proximity, and international research collaboration. Our findings for cultural proximity do not allow of unambiguous conclusions concerning their influence on the collaboration intensity between countries. Linguistic ties among countries are associated with a higher amount of cross-country research collaboration but we find no clear association for historical and colonial linkages.

Suggested Citation

  • Tatiana Plotnikova & Bastian Rake, 2011. "Collaboration in pharmaceutical research: Exploration of country-level determinants," Jena Economics Research Papers 2011-026, Friedrich-Schiller-University Jena.
  • Handle: RePEc:jrp:jrpwrp:2011-026
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    as
    1. Ron A. Boschma & Jan G. Lambooy, 1999. "Evolutionary economics and economic geography," Journal of Evolutionary Economics, Springer, vol. 9(4), pages 411-429.
    2. Pauline Mattsson & Patrice Laget & Anna Nilsson & Carl-Johan Sundberg, 2008. "Intra-EU vs. extra-EU scientific co-publication patterns in EU," Scientometrics, Springer;Akadémiai Kiadó, vol. 75(3), pages 555-574, June.
    3. Susan Bartholomew, 1997. "National Systems of Biotechnology Innovation: Complex Interdependence in the Global System," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 28(2), pages 241-266, June.
    4. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    5. Corinne Autant‐Bernard & Pascal Billand & David Frachisse & Nadine Massard, 2007. "Social distance versus spatial distance in R&D cooperation: Empirical evidence from European collaboration choices in micro and nanotechnologies," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 495-519, August.
    6. Felbermayr, Gabriel J. & Toubal, Farid, 2010. "Cultural proximity and trade," European Economic Review, Elsevier, vol. 54(2), pages 279-293, February.
    7. Jarno Hoekman & Koen Frenken & Frank Oort, 2009. "The geography of collaborative knowledge production in Europe," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 721-738, September.
    8. Mayer, Thierry & Zignago, Soledad, 2006. "Notes on CEPII’s distances measures," MPRA Paper 26469, University Library of Munich, Germany.
    9. Orsenigo, L. & Pammolli, F. & Riccaboni, Massimo, 2001. "Technological change and network dynamics: Lessons from the pharmaceutical industry," Research Policy, Elsevier, vol. 30(3), pages 485-508, March.
    10. Hagedoorn, John, 2002. "Inter-firm R&D partnerships: an overview of major trends and patterns since 1960," Research Policy, Elsevier, vol. 31(4), pages 477-492, May.
    11. Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
    12. Lars Coenen & Jerker Moodysson & Bjørn T. Asheim, 2004. "Nodes, networks and proximities: on the knowledge dynamics of the Medicon Valley biotech cluster," European Planning Studies, Taylor & Francis Journals, vol. 12(7), pages 1003-1018, June.
    13. Uwe Cantner & Andreas Meder, 2007. "Technological proximity and the choice of cooperation partner," Journal of Economic Interaction and Coordination, Springer;Society for Economic Science with Heterogeneous Interacting Agents, vol. 2(1), pages 45-65, June.
    14. Roderik Ponds & Frank Van Oort & Koen Frenken, 2007. "The geographical and institutional proximity of research collaboration," Papers in Regional Science, Wiley Blackwell, vol. 86(3), pages 423-443, August.
    15. Giovanni Dosi & Keith Pavitt & Luc Soete, 1990. "The Economics of Technical Change and International Trade," LEM Book Series, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy, number dosietal-1990, November.
    16. Bjørn Asheim & Lars Coenen & Jan Vang, 2007. "Face-to-Face, Buzz, and Knowledge Bases: Sociospatial Implications for Learning, Innovation, and Innovation Policy," Environment and Planning C, , vol. 25(5), pages 655-670, October.
    17. Thomas Scherngell & Yuanjia Hu, 2011. "Collaborative Knowledge Production in China: Regional Evidence from a Gravity Model Approach," Regional Studies, Taylor & Francis Journals, vol. 45(6), pages 755-772.
    18. Elhanan Helpman & Marc Melitz & Yona Rubinstein, 2008. "Estimating Trade Flows: Trading Partners and Trading Volumes," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 123(2), pages 441-487.
    19. Jarno Hoekman & Thomas Scherngell & Koen Frenken & Robert Tijssen, 2013. "Acquisition of European research funds and its effect on international scientific collaboration," Journal of Economic Geography, Oxford University Press, vol. 13(1), pages 23-52, January.
    20. Christian Zeller, 2004. "North Atlantic Innovative Relations of Swiss Pharmaceuticals and the Proximities with Regional Biotech Arenas," Economic Geography, Taylor & Francis Journals, vol. 80(1), pages 83-111, January.
    21. Walter Isard & Merton J. Peck, 1954. "Location Theory and International and Interregional Trade Theory," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 68(1), pages 97-114.
    22. Grit Laudel, 2002. "What do we measure by co-authorships?," Research Evaluation, Oxford University Press, vol. 11(1), pages 3-15, April.
    23. Katz, J. Sylvan & Martin, Ben R., 1997. "What is research collaboration?," Research Policy, Elsevier, vol. 26(1), pages 1-18, March.
    24. Manuel Acosta & Daniel Coronado & Esther Ferrándiz & M. Dolores León, 2011. "Factors affecting inter-regional academic scientific collaboration within Europe: the role of economic distance," Scientometrics, Springer;Akadémiai Kiadó, vol. 87(1), pages 63-74, April.
    25. Melitz, Jacques, 2008. "Language and foreign trade," European Economic Review, Elsevier, vol. 52(4), pages 667-699, May.
    26. András Schubert & Wolfgang Glänzel, 2006. "Cross-national preference in co-authorship, references and citations," Scientometrics, Springer;Akadémiai Kiadó, vol. 69(2), pages 409-428, November.
    27. Adams, James D. & Black, Grant C. & Clemmons, J. Roger & Stephan, Paula E., 2005. "Scientific teams and institutional collaborations: Evidence from U.S. universities, 1981-1999," Research Policy, Elsevier, vol. 34(3), pages 259-285, April.
    28. Martijn Burger & Frank van Oort & Gert-Jan Linders, 2009. "On the Specification of the Gravity Model of Trade: Zeros, Excess Zeros and Zero-inflated Estimation," Spatial Economic Analysis, Taylor & Francis Journals, vol. 4(2), pages 167-190.
    29. Sujin Choi, 2012. "Core-periphery, new clusters, or rising stars?: international scientific collaboration among ‘advanced’ countries in the era of globalization," Scientometrics, Springer;Akadémiai Kiadó, vol. 90(1), pages 25-41, January.
    30. Jaffe, Adam B, 1986. "Technological Opportunity and Spillovers of R&D: Evidence from Firms' Patents, Profits, and Market Value," American Economic Review, American Economic Association, vol. 76(5), pages 984-1001, December.
    31. Gassmann, Oliver & von Zedtwitz, Maximilian, 1999. "New concepts and trends in international R&D organization," Research Policy, Elsevier, vol. 28(2-3), pages 231-250, March.
    32. Vuong, Quang H, 1989. "Likelihood Ratio Tests for Model Selection and Non-nested Hypotheses," Econometrica, Econometric Society, vol. 57(2), pages 307-333, March.
    33. Jonas Lundberg & Göran Tomson & Inger Lundkvist & John Sk?r & Mats Brommels, 2006. "Collaboration uncovered: Exploring the adequacy of measuring university-industry collaboration through co-authorship and funding," Scientometrics, Springer;Akadémiai Kiadó, vol. 69(3), pages 575-589, December.
    34. Michel Zitt & Elise Bassecoulard & Yoshiko Okubo, 2000. "Shadows of the Past in International Cooperation: Collaboration Profiles of the Top Five Producers of Science," Scientometrics, Springer;Akadémiai Kiadó, vol. 47(3), pages 627-657, March.
    35. Audretsch, David B & Feldman, Maryann P, 1996. "R&D Spillovers and the Geography of Innovation and Production," American Economic Review, American Economic Association, vol. 86(3), pages 630-640, June.
    36. Tijssen, Robert J. W., 2004. "Is the commercialisation of scientific research affecting the production of public knowledge?: Global trends in the output of corporate research articles," Research Policy, Elsevier, vol. 33(5), pages 709-733, July.
    37. Pierre-Alexandre Balland, 2012. "Proximity and the Evolution of Collaboration Networks: Evidence from Research and Development Projects within the Global Navigation Satellite System (GNSS) Industry," Regional Studies, Taylor & Francis Journals, vol. 46(6), pages 741-756, September.
    38. J. M. C. Santos Silva & Silvana Tenreyro, 2006. "The Log of Gravity," The Review of Economics and Statistics, MIT Press, vol. 88(4), pages 641-658, November.
    39. Roberto Basile & Roberta Capello & Andrea Caragliu, 2012. "Technological interdependence and regional growth in Europe: Proximity and synergy in knowledge spillovers," Papers in Regional Science, Wiley Blackwell, vol. 91(4), pages 697-722, November.
    40. Andre Torre & Alain Rallet, 2005. "Proximity and Localization," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 47-59.
    41. Furman, Jeffrey L. & Porter, Michael E. & Stern, Scott, 2002. "The determinants of national innovative capacity," Research Policy, Elsevier, vol. 31(6), pages 899-933, August.
    42. Giovanni Peri, 2005. "Determinants of Knowledge Flows and Their Effect on Innovation," The Review of Economics and Statistics, MIT Press, vol. 87(2), pages 308-322, May.
    43. Gambardella,Alfonso, 1995. "Science and Innovation," Cambridge Books, Cambridge University Press, number 9780521451185, January.
    44. Tom Broekel & Ron Boschma, 2012. "Knowledge networks in the Dutch aviation industry: the proximity paradox," Journal of Economic Geography, Oxford University Press, vol. 12(2), pages 409-433, March.
    45. Nelius Boshoff, 2009. "Neo-colonialism and research collaboration in Central Africa," Scientometrics, Springer;Akadémiai Kiadó, vol. 81(2), pages 413-434, November.
    46. Thomas Scherngell & Michael J. Barber, 2009. "Spatial interaction modelling of cross‐region R&D collaborations: empirical evidence from the 5th EU framework programme," Papers in Regional Science, Wiley Blackwell, vol. 88(3), pages 531-546, August.
    47. Cameron, A. Colin & Trivedi, Pravin K., 1990. "Regression-based tests for overdispersion in the Poisson model," Journal of Econometrics, Elsevier, vol. 46(3), pages 347-364, December.
    48. William H. Greene, 1994. "Accounting for Excess Zeros and Sample Selection in Poisson and Negative Binomial Regression Models," Working Papers 94-10, New York University, Leonard N. Stern School of Business, Department of Economics.
    49. Andr Torre Shaw & Jean-Pierre Gilly, 2000. "On the Analytical Dimension of Proximity Dynamics," Regional Studies, Taylor & Francis Journals, vol. 34(2), pages 169-180.
    50. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    51. Thomas Scherngell & Michael Barber, 2011. "Distinct spatial characteristics of industrial and public research collaborations: evidence from the fifth EU Framework Programme," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 46(2), pages 247-266, April.
    52. Walter Isard, 1954. "Location Theory and Trade Theory: Short-Run Analysis," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 68(2), pages 305-320.
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    More about this item

    Keywords

    International Cooperation; Pharmaceuticals; Proximity;
    All these keywords.

    JEL classification:

    • R10 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General Regional Economics - - - General
    • O31 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives

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