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Benchmark Dose of Lead Inducing Anemia at the Workplace

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  • Kanae Karita
  • Eiji Yano
  • Miwako Dakeishi
  • Toyoto Iwata
  • Katsuyuki Murata

Abstract

To estimate the critical dose of lead inducing anemia in humans, the effects of lead on hemoglobin (Hb) and hematocrit (Hct) levels and red blood cell (RBC) count were examined in 388 male lead‐exposed workers with blood lead (BPb) levels of 0.05–5.5 (mean 1.3) μmol/L by using the benchmark dose (BMD) approach. The BPb level was significantly related to Hb (regression coefficient β=–0.276), RBC (β=–11.35), and Hct (β=–0.563) among the workers (p

Suggested Citation

  • Kanae Karita & Eiji Yano & Miwako Dakeishi & Toyoto Iwata & Katsuyuki Murata, 2005. "Benchmark Dose of Lead Inducing Anemia at the Workplace," Risk Analysis, John Wiley & Sons, vol. 25(4), pages 957-962, August.
    • Handle: RePEc:wly:riskan:v:25:y:2005:i:4:p:957-962
    DOI: 10.1111/j.1539-6924.2005.00652.x
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    References listed on IDEAS

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    1. Grandjean, P. & Jensen, B.M. & Sando, S.H. & Jorgensen, P.J. & Antonsen, S., 1989. "Delayed blood regeneration in lead exposure: An effect on reserve capacity," American Journal of Public Health, American Public Health Association, vol. 79(10), pages 1385-1388.
    2. Katsuyuki Murata & Esben Budtz‐Jørgensen & Philippe Grandjean, 2002. "Benchmark Dose Calculations for Methylmercury‐Associated Delays on Evoked Potential Latencies in Two Cohorts of Children," Risk Analysis, John Wiley & Sons, vol. 22(3), pages 465-474, June.
    3. Esben Budtz-Jørgensen & Niels Keiding & Philippe Grandjean, 2001. "Benchmark Dose Calculation from Epidemiological Data," Biometrics, The International Biometric Society, vol. 57(3), pages 698-706, September.
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