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Modeling the Evolution of Dynamic Brain Processes During an Associative Learning Experiment

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  • Mark Fiecas
  • Hernando Ombao

Abstract

We develop a new time series model to investigate the dynamic interactions between the nucleus accumbens and the hippocampus during an associative learning experiment. Preliminary analyses indicated that the spectral properties of the local field potentials at these two regions changed over the trials of the experiment. While many models already take into account nonstationarity within a single trial, the evolution of the dynamics across trials is often ignored. Our proposed model, the slowly evolving locally stationary process (SEv-LSP), is designed to capture nonstationarity both within a trial and across trials. We rigorously define the evolving evolutionary spectral density matrix, which we estimate using a two-stage procedure. In the first stage, we compute the within-trial time-localized periodogram matrix. In the second stage, we develop a data-driven approach that combines information from trial-specific local periodogram matrices. Through simulation studies, we show the utility of our proposed method for analyzing time series data with different evolutionary structures. Finally, we use the SEv-LSP model to demonstrate the evolving dynamics between the hippocampus and the nucleus accumbens during an associative learning experiment. Supplementary materials for this article are available online.

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  • Mark Fiecas & Hernando Ombao, 2016. "Modeling the Evolution of Dynamic Brain Processes During an Associative Learning Experiment," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1440-1453, October.
    • Handle: RePEc:taf:jnlasa:v:111:y:2016:i:516:p:1440-1453
    DOI: 10.1080/01621459.2016.1165683
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    References listed on IDEAS

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    4. Freyermuth, Jean-Marc & Ombao, Hernando & von Sachs, Rainer, 2010. "Tree-Structured Wavelet Estimation in a Mixed Effects Model for Spectra of Replicated Time Series," Journal of the American Statistical Association, American Statistical Association, vol. 105(490), pages 634-646.
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    8. Ombao H. C & Raz J. A & von Sachs R. & Malow B. A, 2001. "Automatic Statistical Analysis of Bivariate Nonstationary Time Series," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 543-560, June.
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    10. Ori Rosen & Sally Wood & David S. Stoffer, 2012. "AdaptSPEC: Adaptive Spectral Estimation for Nonstationary Time Series," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(500), pages 1575-1589, December.
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    Cited by:

    1. Chau, Van Vinh & von Sachs, Rainer, 2017. "Positive-Definite Multivariate Spectral Estimation: A Geometric Wavelet Approach," LIDAM Discussion Papers ISBA 2017002, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    2. Chau, Van Vinh & Ombao, Hernando & von Sachs, Rainer, 2017. "Data depth and rank-based tests for covariance and spectral density matrices," LIDAM Discussion Papers ISBA 2017019, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    3. Embleton, Jonathan & Knight, Marina I. & Ombao, Hernando, 2022. "Wavelet testing for a replicate-effect within an ordered multiple-trial experiment," Computational Statistics & Data Analysis, Elsevier, vol. 174(C).
    4. Davide Pigoli & Pantelis Z. Hadjipantelis & John S. Coleman & John A. D. Aston, 2018. "The statistical analysis of acoustic phonetic data: exploring differences between spoken Romance languages," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 67(5), pages 1103-1145, November.
    5. Chau, Joris & von Sachs, Rainer, 2022. "Time-varying spectral matrix estimation via intrinsic wavelet regression for surfaces of Hermitian positive definite matrices," Computational Statistics & Data Analysis, Elsevier, vol. 174(C).
    6. Charles Fontaine & Ron D. Frostig & Hernando Ombao, 2020. "Modeling dependence via copula of functionals of Fourier coefficients," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 29(4), pages 1125-1144, December.
    7. Boland, Joanna & Telesca, Donatello & Sugar, Catherine & Jeste, Shafali & Goldbeck, Cameron & Senturk, Damla, 2022. "A study of longitudinal trends in time-frequency transformations of EEG data during a learning experiment," Computational Statistics & Data Analysis, Elsevier, vol. 167(C).
    8. Chau, Van Vinh & von Sachs, Rainer, 2016. "Functional mixed effects wavelet estimation for spectra of replicated time series," LIDAM Discussion Papers ISBA 2016013, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    9. Chau, Van Vinh & von Sachs, Rainer, 2018. "Intrinsic wavelet regression for surfaces of Hermitian positive definite matrices," LIDAM Discussion Papers ISBA 2018025, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    10. Fontaine, Charles & Frostig, Ron D. & Ombao, Hernando, 2020. "Modeling non-linear spectral domain dependence using copulas with applications to rat local field potentials," Econometrics and Statistics, Elsevier, vol. 15(C), pages 85-103.
    11. Scott A. Bruce & Martica H. Hall & Daniel J. Buysse & Robert T. Krafty, 2018. "Conditional adaptive Bayesian spectral analysis of nonstationary biomedical time series," Biometrics, The International Biometric Society, vol. 74(1), pages 260-269, March.
    12. Degras, David & Ting, Chee-Ming & Ombao, Hernando, 2022. "Markov-switching state-space models with applications to neuroimaging," Computational Statistics & Data Analysis, Elsevier, vol. 174(C).
    13. Park, Jun Young & Polzehl, Joerg & Chatterjee, Snigdhansu & Brechmann, André & Fiecas, Mark, 2020. "Semiparametric modeling of time-varying activation and connectivity in task-based fMRI data," Computational Statistics & Data Analysis, Elsevier, vol. 150(C).
    14. Brian Hart & Michele Guindani & Stephen Malone & Mark Fiecas, 2022. "A nonparametric Bayesian model for estimating spectral densities of resting‐state EEG twin data," Biometrics, The International Biometric Society, vol. 78(1), pages 313-323, March.
    15. Zhang, Shibin, 2020. "Nonparametric Bayesian inference for the spectral density based on irregularly spaced data," Computational Statistics & Data Analysis, Elsevier, vol. 151(C).
    16. von Sachs, Rainer, 2019. "Spectral Analysis of Multivariate Time Series," LIDAM Discussion Papers ISBA 2019008, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).

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