IDEAS home Printed from https://ideas.repec.org/a/spr/stabio/v16y2024i2d10.1007_s12561-023-09407-4.html
   My bibliography  Save this article

Evaluating Effects of Various Exposures on Mortality Risk of Opioid Use Disorders with Linked Administrative Databases

Author

Listed:
  • Trevor J. Thomson

    (Simon Fraser University)

  • X. Joan Hu

    (Simon Fraser University)

  • Bohdan Nosyk

    (St. Paul’s Hospital
    Simon Fraser University)

Abstract

Administrative health records provide a rich source of information pertaining to various exposures, many of which are time-varying in nature. When internal time-varying covariates are included in a Cox regression model, likelihood-based inference procedures are no longer applicable to infer model parameters (Kalbfleisch and Prentice in The Statistical analysis of failure time data, Wiley, New York, 2002). Motivated by the ongoing opioid epidemic, we summarize an individual’s opioid agonist treatment (OAT) dispensation history and additional exposures with (i) a model-based summary, or (ii) its functional principal component scores. We show that the OAT dispensation proportion has a non-linear effect on the mortality hazard over time, and a significant interaction with time of birth. Particularly a clear protective effect against mortality for Millennials and Generation Z is revealed. Our approach is easy to implement by virtually any statistical software, and provides a risk assessment tool for utilizing available health records.

Suggested Citation

  • Trevor J. Thomson & X. Joan Hu & Bohdan Nosyk, 2024. "Evaluating Effects of Various Exposures on Mortality Risk of Opioid Use Disorders with Linked Administrative Databases," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 16(2), pages 416-434, July.
    • Handle: RePEc:spr:stabio:v:16:y:2024:i:2:d:10.1007_s12561-023-09407-4
    DOI: 10.1007/s12561-023-09407-4
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s12561-023-09407-4
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s12561-023-09407-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Fushing Hsieh & Yi-Kuan Tseng & Jane-Ling Wang, 2006. "Joint Modeling of Survival and Longitudinal Data: Likelihood Approach Revisited," Biometrics, The International Biometric Society, vol. 62(4), pages 1037-1043, December.
    2. Jimin Ding & Jane-Ling Wang, 2008. "Modeling Longitudinal Data with Nonparametric Multiplicative Random Effects Jointly with Survival Data," Biometrics, The International Biometric Society, vol. 64(2), pages 546-556, June.
    3. John A. Rice & Colin O. Wu, 2001. "Nonparametric Mixed Effects Models for Unequally Sampled Noisy Curves," Biometrics, The International Biometric Society, vol. 57(1), pages 253-259, March.
    4. L. Wu & W. Liu & X. J. Hu, 2010. "Joint Inference on HIV Viral Dynamics and Immune Suppression in Presence of Measurement Errors," Biometrics, The International Biometric Society, vol. 66(2), pages 327-335, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yih‐Huei Huang & Wen‐Han Hwang & Fei‐Yin Chen, 2016. "Improving efficiency using the Rao–Blackwell theorem in corrected and conditional score estimation methods for joint models," Biometrics, The International Biometric Society, vol. 72(4), pages 1136-1144, December.
    2. Jian-Jian Ren & Yuyin Shi, 2024. "Empirical likelihood MLE for joint modeling right censored survival data with longitudinal covariates," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 76(4), pages 617-648, August.
    3. Lisa M. McCrink & Adele H. Marshall & Karen J. Cairns, 2013. "Advances in Joint Modelling: A Review of Recent Developments with Application to the Survival of End Stage Renal Disease Patients," International Statistical Review, International Statistical Institute, vol. 81(2), pages 249-269, August.
    4. repec:jss:jstsof:35:i09 is not listed on IDEAS
    5. Rizopoulos, Dimitris, 2012. "Fast fitting of joint models for longitudinal and event time data using a pseudo-adaptive Gaussian quadrature rule," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 491-501.
    6. Y. K. Tseng & Y. R. Su & M. Mao & J. L. Wang, 2015. "An extended hazard model with longitudinal covariates," Biometrika, Biometrika Trust, vol. 102(1), pages 135-150.
    7. Jaeun Choi & Donglin Zeng & Andrew F. Olshan & Jianwen Cai, 2018. "Joint modeling of survival time and longitudinal outcomes with flexible random effects," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 126-152, January.
    8. Jimin Ding & Jane-Ling Wang, 2008. "Modeling Longitudinal Data with Nonparametric Multiplicative Random Effects Jointly with Survival Data," Biometrics, The International Biometric Society, vol. 64(2), pages 546-556, June.
    9. Chen, Chyong-Mei & Shen, Pao-sheng & Tseng, Yi-Kuan, 2018. "Semiparametric transformation joint models for longitudinal covariates and interval-censored failure time," Computational Statistics & Data Analysis, Elsevier, vol. 128(C), pages 116-127.
    10. Atanu B & Gajendra V & Jesna J & Ramesh V, 2017. "Multiple Imputations for Determining an Optimum Biological Dose of a Metronomic Chemotherapy," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 3(5), pages 129-140, October.
    11. Dimitris Rizopoulos & Geert Verbeke & Geert Molenberghs, 2010. "Multiple-Imputation-Based Residuals and Diagnostic Plots for Joint Models of Longitudinal and Survival Outcomes," Biometrics, The International Biometric Society, vol. 66(1), pages 20-29, March.
    12. Shahedul A. Khan & Nyla Basharat, 2022. "Accelerated failure time models for recurrent event data analysis and joint modeling," Computational Statistics, Springer, vol. 37(4), pages 1569-1597, September.
    13. Walter Dempsey & Peter McCullagh, 2018. "Survival models and health sequences," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(4), pages 550-584, October.
    14. Jaroslaw Harezlak & Louise M. Ryan & Jay N. Giedd & Nicholas Lange, 2005. "Individual and Population Penalized Regression Splines for Accelerated Longitudinal Designs," Biometrics, The International Biometric Society, vol. 61(4), pages 1037-1048, December.
    15. Ye, Mao & Lu, Zhao-Hua & Li, Yimei & Song, Xinyuan, 2019. "Finite mixture of varying coefficient model: Estimation and component selection," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 452-474.
    16. Wei Liu & Lang Wu, 2007. "Simultaneous Inference for Semiparametric Nonlinear Mixed-Effects Models with Covariate Measurement Errors and Missing Responses," Biometrics, The International Biometric Society, vol. 63(2), pages 342-350, June.
    17. Lei Liu & Xuelin Huang & John O'Quigley, 2008. "Analysis of Longitudinal Data in the Presence of Informative Observational Times and a Dependent Terminal Event, with Application to Medical Cost Data," Biometrics, The International Biometric Society, vol. 64(3), pages 950-958, September.
    18. Esra Kürüm & Danh V. Nguyen & Qi Qian & Sudipto Banerjee & Connie M. Rhee & Damla Şentürk, 2024. "Spatiotemporal multilevel joint modeling of longitudinal and survival outcomes in end-stage kidney disease," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 30(4), pages 827-852, October.
    19. Roula Tsonaka & Geert Verbeke & Emmanuel Lesaffre, 2009. "A Semi-Parametric Shared Parameter Model to Handle Nonmonotone Nonignorable Missingness," Biometrics, The International Biometric Society, vol. 65(1), pages 81-87, March.
    20. Tang, Nian-Sheng & Tang, An-Min & Pan, Dong-Dong, 2014. "Semiparametric Bayesian joint models of multivariate longitudinal and survival data," Computational Statistics & Data Analysis, Elsevier, vol. 77(C), pages 113-129.
    21. Dimitris Rizopoulos, 2011. "Dynamic Predictions and Prospective Accuracy in Joint Models for Longitudinal and Time-to-Event Data," Biometrics, The International Biometric Society, vol. 67(3), pages 819-829, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:stabio:v:16:y:2024:i:2:d:10.1007_s12561-023-09407-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.