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Multiple Imputations for Determining an Optimum Biological Dose of a Metronomic Chemotherapy

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  • Atanu B

    (Centre for Cancer Epidemiology,The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC),Tata Memorial Centre, Mumbai, India)

  • Gajendra V

    (Department of Applied Mathematics, Indian Institute of Technology -Dhanbad- 826004, India.)

  • Jesna J

    (Department of Applied Mathematics, Indian Institute of Technology -Dhanbad- 826004, India.)

  • Ramesh V

    (King Abdullah International Medical Research Center (KAIMRC),King Saud Bin Abdulaziz University for Health Sciences,Ministry of National Guard-Health Affairs,Riyadh,Kingdom of Saudi Arabia.)

Abstract

The doses of chemotherapy selected in clinical practice are routinely obtained by the Maximum Tolerated Dose (MTD) approaches. It is believed that an increase in dose will lead to an increase in tumor response. The effect on angiogenesis is achieved by targeting Circulating Endothelial Cell(CEC). The effect on CEC is restricted to an antiangiogenic window in tumor cell line studies The challenge is to establish the optimal biological dose (OBD) of MC which would have maximized inhibiting effect on CEC.

Suggested Citation

  • Atanu B & Gajendra V & Jesna J & Ramesh V, 2017. "Multiple Imputations for Determining an Optimum Biological Dose of a Metronomic Chemotherapy," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 3(5), pages 129-140, October.
    • Handle: RePEc:adp:jbboaj:v:3:y:2017:i:5:p:129-140
    DOI: 10.19080/BBOAJ.2017.03.555621
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    References listed on IDEAS

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