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An EM algorithm for the estimation of parameters of a flexible cure rate model with generalized gamma lifetime and model discrimination using likelihood- and information-based methods

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  • N. Balakrishnan
  • Suvra Pal

Abstract

In this paper, we consider the Conway–Maxwell Poisson (COM-Poisson) cure rate model based on a competing risks scenario. This model includes, as special cases, some of the well-known cure rate models discussed in the literature. By assuming the time-to-event to follow the generalized gamma distribution, which contains some of the commonly used lifetime distributions as special cases, we develop exact likelihood inference based on the expectation maximization algorithm. The standard errors of the maximum likelihood estimates are obtained by inverting the observed information matrix. An extensive Monte Carlo simulation study is performed to examine the method of inference developed here. Model discrimination within the generalized gamma family is also carried out by means of likelihood- and information-based methods to select the particular lifetime distribution that provides an adequate fit to the data. Finally, a data on cancer recurrence is analyzed to illustrate the flexibility of the COM-Poisson family and the generalized gamma family so as to select a parsimonious competing cause distribution and a lifetime distribution that jointly provide an adequate fit to the data. Copyright Springer-Verlag Berlin Heidelberg 2015

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  • N. Balakrishnan & Suvra Pal, 2015. "An EM algorithm for the estimation of parameters of a flexible cure rate model with generalized gamma lifetime and model discrimination using likelihood- and information-based methods," Computational Statistics, Springer, vol. 30(1), pages 151-189, March.
    • Handle: RePEc:spr:compst:v:30:y:2015:i:1:p:151-189
    DOI: 10.1007/s00180-014-0527-9
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    References listed on IDEAS

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    1. Balakrishnan, N. & Pal, Suvra, 2013. "Lognormal lifetimes and likelihood-based inference for flexible cure rate models based on COM-Poisson family," Computational Statistics & Data Analysis, Elsevier, vol. 67(C), pages 41-67.
    2. Borges, Patrick & Rodrigues, Josemar & Balakrishnan, Narayanaswamy, 2012. "Correlated destructive generalized power series cure rate models and associated inference with an application to a cutaneous melanoma data," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 1703-1713.
    3. Judy P. Sy & Jeremy M. G. Taylor, 2000. "Estimation in a Cox Proportional Hazards Cure Model," Biometrics, The International Biometric Society, vol. 56(1), pages 227-236, March.
    4. Gerda Claeskens & Rosemary Nguti & Paul Janssen, 2008. "One-sided tests in shared frailty models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 17(1), pages 69-82, May.
    5. Galit Shmueli & Thomas P. Minka & Joseph B. Kadane & Sharad Borle & Peter Boatwright, 2005. "A useful distribution for fitting discrete data: revival of the Conway–Maxwell–Poisson distribution," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(1), pages 127-142, January.
    6. Cooner, Freda & Banerjee, Sudipto & Carlin, Bradley P. & Sinha, Debajyoti, 2007. "Flexible Cure Rate Modeling Under Latent Activation Schemes," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 560-572, June.
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    1. Amanda D’Andrea & Ricardo Rocha & Vera Tomazella & Francisco Louzada, 2018. "Negative Binomial Kumaraswamy-G Cure Rate Regression Model," JRFM, MDPI, vol. 11(1), pages 1-14, January.
    2. Suvra Pal & Yingwei Peng & Wisdom Aselisewine, 2024. "A new approach to modeling the cure rate in the presence of interval censored data," Computational Statistics, Springer, vol. 39(5), pages 2743-2769, July.
    3. Pal, Suvra & Balakrishnan, N., 2016. "Destructive negative binomial cure rate model and EM-based likelihood inference under Weibull lifetime," Statistics & Probability Letters, Elsevier, vol. 116(C), pages 9-20.
    4. Suvra Pal & Hongbo Yu & Zachary D. Loucks & Ian M. Harris, 2020. "Illustration of the Flexibility of Generalized Gamma Distribution in Modeling Right Censored Survival Data: Analysis of Two Cancer Datasets," Annals of Data Science, Springer, vol. 7(1), pages 77-90, March.
    5. Suvra Pal & N. Balakrishnan, 2017. "Likelihood inference for the destructive exponentially weighted Poisson cure rate model with Weibull lifetime and an application to melanoma data," Computational Statistics, Springer, vol. 32(2), pages 429-449, June.
    6. Rocha, Ricardo & Nadarajah, Saralees & Tomazella, Vera & Louzada, Francisco, 2017. "A new class of defective models based on the Marshall–Olkin family of distributions for cure rate modeling," Computational Statistics & Data Analysis, Elsevier, vol. 107(C), pages 48-63.
    7. Nanami Taketomi & Kazuki Yamamoto & Christophe Chesneau & Takeshi Emura, 2022. "Parametric Distributions for Survival and Reliability Analyses, a Review and Historical Sketch," Mathematics, MDPI, vol. 10(20), pages 1-23, October.
    8. Suvra Pal & Jacob Majakwara & N. Balakrishnan, 2018. "An EM algorithm for the destructive COM-Poisson regression cure rate model," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 81(2), pages 143-171, February.
    9. Suvra Pal & Souvik Roy, 2021. "On the estimation of destructive cure rate model: A new study with exponentially weighted Poisson competing risks," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 75(3), pages 324-342, August.

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