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Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

Author

Listed:
  • Martin Gaksch
  • Rolf Jorde
  • Guri Grimnes
  • Ragnar Joakimsen
  • Henrik Schirmer
  • Tom Wilsgaard
  • Ellisiv B Mathiesen
  • Inger Njølstad
  • Maja-Lisa Løchen
  • Winfried März
  • Marcus E Kleber
  • Andreas Tomaschitz
  • Martin Grübler
  • Gudny Eiriksdottir
  • Elias F Gudmundsson
  • Tamara B Harris
  • Mary F Cotch
  • Thor Aspelund
  • Vilmundur Gudnason
  • Femke Rutters
  • Joline W J Beulens
  • Esther van ‘t Riet
  • Giel Nijpels
  • Jacqueline M Dekker
  • Diana Grove-Laugesen
  • Lars Rejnmark
  • Markus A Busch
  • Gert B M Mensink
  • Christa Scheidt-Nave
  • Michael Thamm
  • Karin M A Swart
  • Ingeborg A Brouwer
  • Paul Lips
  • Natasja M van Schoor
  • Christopher T Sempos
  • Ramón A Durazo-Arvizu
  • Zuzana Škrabáková
  • Kirsten G Dowling
  • Kevin D Cashman
  • Mairead Kiely
  • Stefan Pilz

Abstract

Background: Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality. Methods: In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488. Findings: We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, and

Suggested Citation

  • Martin Gaksch & Rolf Jorde & Guri Grimnes & Ragnar Joakimsen & Henrik Schirmer & Tom Wilsgaard & Ellisiv B Mathiesen & Inger Njølstad & Maja-Lisa Løchen & Winfried März & Marcus E Kleber & Andreas Tom, 2017. "Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0170791
    DOI: 10.1371/journal.pone.0170791
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    References listed on IDEAS

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