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Effects of Treatment with Zofenopril in Men and Women with Acute Myocardial Infarction: Gender Analysis of the SMILE Program

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  • Flavia Franconi
  • Stefano Omboni
  • Ettore Ambrosioni
  • Giorgio Reggiardo
  • Ilaria Campesi
  • Claudio Borghi

Abstract

Background: the SMILE studies proved the prognostic benefit of zofenopril vs. placebo or other ACE-inhibitors (ACEIs) in post-acute myocardial infarction (AMI). In this retrospective pooled analysis of these studies we assessed whether the zofenopril effect is influenced by gender. Methods: the four double-blind, randomized, parallel-group SMILE studies, compared the efficacy and safety of 6–48 week treatment with zofenopril 60 mg/day with that of placebo, lisinopril 10 mg/day or ramipril 10 mg/day in 3630 AMI patients. This pooled analysis compared treatment efficacy (1-year combined occurrence of death or hospitalization for CV causes) in 2733 men and 897 women. Results: women were older than men, had a higher prevalence of diabetes and of other major CV risk factors. The risk of a major CV event was significantly larger for women (23% vs. 17% men, p

Suggested Citation

  • Flavia Franconi & Stefano Omboni & Ettore Ambrosioni & Giorgio Reggiardo & Ilaria Campesi & Claudio Borghi, 2014. "Effects of Treatment with Zofenopril in Men and Women with Acute Myocardial Infarction: Gender Analysis of the SMILE Program," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0111558
    DOI: 10.1371/journal.pone.0111558
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    1. Thomas P A Debray & Karel G M Moons & Ghada Mohammed Abdallah Abo-Zaid & Hendrik Koffijberg & Richard David Riley, 2013. "Individual Participant Data Meta-Analysis for a Binary Outcome: One-Stage or Two-Stage?," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
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