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Effectiveness of Internet- and Mobile-Based Cognitive Behavioral Therapy to Reduce Suicidal Ideation and Behaviors: Protocol for a Systematic Review and Meta-Analysis of Individual Participant Data

Author

Listed:
  • Rebekka Büscher

    (Department of Rehabilitation Psychology and Psychotherapy, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany)

  • Marie Beisemann

    (Department of Statistics, TU Dortmund University, 44227 Dortmund, Germany)

  • Philipp Doebler

    (Department of Statistics, TU Dortmund University, 44227 Dortmund, Germany)

  • Lena Steubl

    (Department of Clinical Psychology and Psychotherapy, Ulm University, 89069 Ulm, Germany)

  • Matthias Domhardt

    (Department of Clinical Psychology and Psychotherapy, Ulm University, 89069 Ulm, Germany)

  • Pim Cuijpers

    (Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands)

  • Ad Kerkhof

    (Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands)

  • Lasse B. Sander

    (Department of Rehabilitation Psychology and Psychotherapy, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany)

Abstract

Internet- and mobile-based cognitive behavioral therapy (iCBT) might reduce suicidal ideation. However, recent meta-analyses found small effect sizes, and it remains unclear whether specific subgroups of participants experience beneficial or harmful effects. This is the study protocol for an individual participant meta-analysis (IPD-MA) aiming to determine the effectiveness of iCBT on suicidal ideation and identify moderators. We will systematically search CENTRAL, PsycINFO, Embase, and Pubmed for randomized controlled trials examining guided or self-guided iCBT for suicidality. All types of control conditions are eligible. Participants experiencing suicidal ideation will be included irrespective of age, diagnoses, or co-interventions. We will conduct a one-stage IPD-MA with suicidal ideation as the primary outcome, using a continuous measure, reliable improvement and deterioration, and response rate. Moderator analyses will be performed on participant-, study-, and intervention-level. Two independent reviewers will assess risk of bias and the quality of evidence using Cochrane’s Risk of Bias Tool 2 and GRADE. This review was registered with OSF and is currently in progress. The IPD-MA will provide effect estimates while considering covariates and will offer novel insights into differential effects on a participant level. This will help to develop more effective, safe, and tailored digital treatment options for suicidal individuals.

Suggested Citation

  • Rebekka Büscher & Marie Beisemann & Philipp Doebler & Lena Steubl & Matthias Domhardt & Pim Cuijpers & Ad Kerkhof & Lasse B. Sander, 2020. "Effectiveness of Internet- and Mobile-Based Cognitive Behavioral Therapy to Reduce Suicidal Ideation and Behaviors: Protocol for a Systematic Review and Meta-Analysis of Individual Participant Data," IJERPH, MDPI, vol. 17(14), pages 1-11, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5179-:d:386169
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    References listed on IDEAS

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    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
    2. Helen Christensen & Philip J. Batterham & Bridianne O'Dea, 2014. "E-Health Interventions for Suicide Prevention," IJERPH, MDPI, vol. 11(8), pages 1-20, August.
    3. Thomas P A Debray & Karel G M Moons & Ghada Mohammed Abdallah Abo-Zaid & Hendrik Koffijberg & Richard David Riley, 2013. "Individual Participant Data Meta-Analysis for a Binary Outcome: One-Stage or Two-Stage?," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
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