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Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

Author

Listed:
  • Jennifer K Frediani
  • Dean P Jones
  • Nestan Tukvadze
  • Karan Uppal
  • Eka Sanikidze
  • Maia Kipiani
  • ViLinh T Tran
  • Gautam Hebbar
  • Douglas I Walker
  • Russell R Kempker
  • Shaheen S Kurani
  • Romain A Colas
  • Jesmond Dalli
  • Vin Tangpricha
  • Charles N Serhan
  • Henry M Blumberg
  • Thomas R Ziegler

Abstract

We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well as biomarkers of TB onset, progression and resolution. Such data may inform development of new anti-tuberculosis drugs. Plasma samples from adults with newly diagnosed pulmonary TB disease and their matched, asymptomatic, sputum culture-negative household contacts were analyzed using liquid chromatography high-resolution mass spectrometry (LC-MS) to identify metabolites. Statistical and bioinformatics methods were used to select accurate mass/charge (m/z) ions that were significantly different between the two groups at a false discovery rate (FDR) of q

Suggested Citation

  • Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0108854
    DOI: 10.1371/journal.pone.0108854
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    References listed on IDEAS

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    1. Matthew Spite & Lucy V. Norling & Lisa Summers & Rong Yang & Dianne Cooper & Nicos A. Petasis & Roderick J. Flower & Mauro Perretti & Charles N. Serhan, 2009. "Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis," Nature, Nature, vol. 461(7268), pages 1287-1291, October.
    2. James R Roede & Karan Uppal & Youngja Park & Kichun Lee & Vilinh Tran & Douglas Walker & Frederick H Strobel & Shannon L Rhodes & Beate Ritz & Dean P Jones, 2013. "Serum Metabolomics of Slow vs. Rapid Motor Progression Parkinson’s Disease: a Pilot Study," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    3. Charles N. Serhan, 2014. "Pro-resolving lipid mediators are leads for resolution physiology," Nature, Nature, vol. 510(7503), pages 92-101, June.
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