IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0077629.html
   My bibliography  Save this article

Serum Metabolomics of Slow vs. Rapid Motor Progression Parkinson’s Disease: a Pilot Study

Author

Listed:
  • James R Roede
  • Karan Uppal
  • Youngja Park
  • Kichun Lee
  • Vilinh Tran
  • Douglas Walker
  • Frederick H Strobel
  • Shannon L Rhodes
  • Beate Ritz
  • Dean P Jones

Abstract

Progression of Parkinson’s disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet, environmental exposures and health behaviors. In this pilot study, we employed high resolution mass spectrometry-based metabolic profiling to investigate the metabolic signatures of slow versus rapidly progressing PD present in human serum. Archival serum samples from PD patients obtained within 3 years of disease onset were analyzed via dual chromatography-high resolution mass spectrometry, with data extraction by xMSanalyzer and used to predict rapid or slow motor progression of these patients during follow-up. Statistical analyses, such as false discovery rate analysis and partial least squares discriminant analysis, yielded a list of statistically significant metabolic features and further investigation revealed potential biomarkers. In particular, N8-acetyl spermidine was found to be significantly elevated in the rapid progressors compared to both control subjects and slow progressors. Our exploratory data indicate that a fast motor progression disease phenotype can be distinguished early in disease using high resolution mass spectrometry-based metabolic profiling and that altered polyamine metabolism may be a predictive marker of rapidly progressing PD.

Suggested Citation

  • James R Roede & Karan Uppal & Youngja Park & Kichun Lee & Vilinh Tran & Douglas Walker & Frederick H Strobel & Shannon L Rhodes & Beate Ritz & Dean P Jones, 2013. "Serum Metabolomics of Slow vs. Rapid Motor Progression Parkinson’s Disease: a Pilot Study," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
  • Handle: RePEc:plo:pone00:0077629
    DOI: 10.1371/journal.pone.0077629
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077629
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077629&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0077629?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Peter Langfelder & Rui Luo & Michael C Oldham & Steve Horvath, 2011. "Is My Network Module Preserved and Reproducible?," PLOS Computational Biology, Public Library of Science, vol. 7(1), pages 1-29, January.
    2. Beate Ritz & Shannon L Rhodes & Yvette Bordelon & Jeff Bronstein, 2012. "α-Synuclein Genetic Variants Predict Faster Motor Symptom Progression in Idiopathic Parkinson Disease," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-8, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiao-Ying Wang & Wen-Yan Kang & Qiong Yang & Lin-Yuan Zhang & Sheng-Di Chen & Jun Liu, 2014. "Using Gastrocnemius sEMG and Plasma α-Synuclein for the Prediction of Freezing of Gait in Parkinson's Disease Patients," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-5, February.
    2. Rinku Sharma & Garima Singh & Sudeepto Bhattacharya & Ashutosh Singh, 2018. "Comparative transcriptome meta-analysis of Arabidopsis thaliana under drought and cold stress," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-18, September.
    3. Shinya Tasaki & Jishu Xu & Denis R. Avey & Lynnaun Johnson & Vladislav A. Petyuk & Robert J. Dawe & David A. Bennett & Yanling Wang & Chris Gaiteri, 2022. "Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Peter Langfelder & Paul S Mischel & Steve Horvath, 2013. "When Is Hub Gene Selection Better than Standard Meta-Analysis?," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-16, April.
    5. Jenna Lihavainen & Jan Šimura & Pushan Bag & Nazeer Fataftah & Kathryn Megan Robinson & Nicolas Delhomme & Ondřej Novák & Karin Ljung & Stefan Jansson, 2023. "Salicylic acid metabolism and signalling coordinate senescence initiation in aspen in nature," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Li, Jie & Shen, Xuzhu & Li, YaoTang, 2021. "Modeling the temporal dynamics of gut microbiota from a local community perspective," Ecological Modelling, Elsevier, vol. 460(C).
    7. Kynon J. M. Benjamin & Ria Arora & Arthur S. Feltrin & Geo Pertea & Hunter H. Giles & Joshua M. Stolz & Laura D’Ignazio & Leonardo Collado-Torres & Joo Heon Shin & William S. Ulrich & Thomas M. Hyde &, 2024. "Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Yuhao Min & Xue Wang & Özkan İş & Tulsi A. Patel & Junli Gao & Joseph S. Reddy & Zachary S. Quicksall & Thuy Nguyen & Shu Lin & Frederick Q. Tutor-New & Jessica L. Chalk & Adriana O. Mitchell & Julia , 2023. "Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    9. Samaneh Mansouri & André M. Pessoni & Arturo Marroquín-Rivera & Eric M. Parise & Carol A. Tamminga & Gustavo Turecki & Eric J. Nestler & Ting-Huei Chen & Benoit Labonté, 2023. "Transcriptional dissection of symptomatic profiles across the brain of men and women with depression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Kazuhisa Shibata & Takeo Watanabe & Mitsuo Kawato & Yuka Sasaki, 2016. "Differential Activation Patterns in the Same Brain Region Led to Opposite Emotional States," PLOS Biology, Public Library of Science, vol. 14(9), pages 1-27, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0077629. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.