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Pro-resolving lipid mediators are leads for resolution physiology

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  • Charles N. Serhan

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School)

Abstract

Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.

Suggested Citation

  • Charles N. Serhan, 2014. "Pro-resolving lipid mediators are leads for resolution physiology," Nature, Nature, vol. 510(7503), pages 92-101, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13479
    DOI: 10.1038/nature13479
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    Cited by:

    1. Hidenori Moriyama & Jin Endo & Masaharu Kataoka & Yuta Shimanaka & Nozomu Kono & Yuki Sugiura & Shinichi Goto & Hiroki Kitakata & Takahiro Hiraide & Naohiro Yoshida & Sarasa Isobe & Tsunehisa Yamamoto, 2022. "Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Girolamo Di Maio & Ines Villano & Ciro Rosario Ilardi & Antonietta Messina & Vincenzo Monda & Ashlei Clara Iodice & Chiara Porro & Maria Antonietta Panaro & Sergio Chieffi & Giovanni Messina & Marcell, 2023. "Mechanisms of Transmission and Processing of Pain: A Narrative Review," IJERPH, MDPI, vol. 20(4), pages 1-19, February.
    3. Rodrigo Zapata B. & José Miguel Müller & Juan Enrique Vásquez & Franco Ravera & Gustavo Lago & Eduardo Cañón & Daniella Castañeda & Madelaine Pradenas & Muriel Ramírez-Santana, 2021. "Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study," IJERPH, MDPI, vol. 18(15), pages 1-8, July.
    4. E. A. Monson & K. M. Crosse & M. Duan & W. Chen & R. D. O’Shea & L. M. Wakim & J. M. Carr & D. R. Whelan & K. J. Helbig, 2021. "Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Melissa Lopez-Pentecost & Brian Hallmark & Cynthia A. Thomson & Floyd Chilton & David O. Garcia, 2023. "Association between Dietary Fatty Acid Intake and Liver Steatosis and Fibrosis in a Sample of Mexican-Origin Hispanic Adults with Overweight or Obesity," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    6. Muriel Ramírez-Santana & Rodrigo Zapata Barra & Marcela Ñunque González & José Miguel Müller & Juan Enrique Vásquez & Franco Ravera & Gustavo Lago & Eduardo Cañón & Daniella Castañeda & Madelaine Prad, 2022. "Inverse Association between Omega-3 Index and Severity of COVID-19: A Case–Control Study," IJERPH, MDPI, vol. 19(11), pages 1-11, May.
    7. Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.
    8. A. Zamora & M. Nougué & L. Verdu & E. Balzan & T. Draia-Nicolau & E. Benuzzi & F. Pujol & V. Baillif & E. Lacazette & F. Morfoisse & J. Galitzky & A. Bouloumié & M. Dubourdeau & B. Chaput & N. Fazille, 2024. "15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Isaac Francos-Quijorna & Marina Sánchez-Petidier & Emily R. Burnside & Smaranda R. Badea & Abel Torres-Espin & Lucy Marshall & Fred Winter & Joost Verhaagen & Victoria Moreno-Manzano & Elizabeth J. Br, 2022. "Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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