IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i4p3103-d1064053.html
   My bibliography  Save this article

Association between Dietary Fatty Acid Intake and Liver Steatosis and Fibrosis in a Sample of Mexican-Origin Hispanic Adults with Overweight or Obesity

Author

Listed:
  • Melissa Lopez-Pentecost

    (Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA)

  • Brian Hallmark

    (The BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA)

  • Cynthia A. Thomson

    (Department of Health Promotion Sciences Tucson, University of Arizona, Tucson, AZ 85721, USA)

  • Floyd Chilton

    (The BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
    Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85721, USA)

  • David O. Garcia

    (Department of Health Promotion Sciences Tucson, University of Arizona, Tucson, AZ 85721, USA)

Abstract

Rates of non-alcoholic fatty liver disease (NAFLD) vary dramatically among Hispanic subpopulations, with Mexican-origin (MO) Hispanics experiencing a disproportionate burden. This study examined dietary fatty acid (FA) intake among overweight and obese MO Hispanic adults in the United States (US) and evaluated its association with liver steatosis and fibrosis. Participants (N = 285, MO Hispanic adults) completed 24-h dietary recalls to assess dietary FA exposure. Liver steatosis and fibrosis were estimated using transient elastography (FibroScan ® ). Multiple regression analysis tested relationships between FA intakes and liver steatosis or fibrosis, adjusting for age, sex, body mass index (BMI) and total energy. A total of 51% (n = 145) of participants were suspected to have NAFLD and 20% self-reported a type 2 diabetes diagnosis. No significant association was observed between Linoleic Acid and α-Linolenic Acid (LA:ALA) ratio, or omega-6 to omega-3 (n-6:n-3) ratio and liver steatosis. However, a one-point increase in the LA:ALA ratio resulted in a 1.01% increase in the liver fibrosis scores (95% CI: [1.00, 1.03]; p = 0.03), and a one-point increase in the n-6:n-3 ratio resulted in a 1.02% increase in liver fibrosis score (95% CI: [1.01, 1.03]; p = 0.01). Further research is needed to determine if modulation of FA intake could reduce NAFLD risk in this high-risk population.

Suggested Citation

  • Melissa Lopez-Pentecost & Brian Hallmark & Cynthia A. Thomson & Floyd Chilton & David O. Garcia, 2023. "Association between Dietary Fatty Acid Intake and Liver Steatosis and Fibrosis in a Sample of Mexican-Origin Hispanic Adults with Overweight or Obesity," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3103-:d:1064053
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/4/3103/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/4/3103/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Charles N. Serhan, 2014. "Pro-resolving lipid mediators are leads for resolution physiology," Nature, Nature, vol. 510(7503), pages 92-101, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Rodrigo Zapata B. & José Miguel Müller & Juan Enrique Vásquez & Franco Ravera & Gustavo Lago & Eduardo Cañón & Daniella Castañeda & Madelaine Pradenas & Muriel Ramírez-Santana, 2021. "Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study," IJERPH, MDPI, vol. 18(15), pages 1-8, July.
    2. Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.
    3. A. Zamora & M. Nougué & L. Verdu & E. Balzan & T. Draia-Nicolau & E. Benuzzi & F. Pujol & V. Baillif & E. Lacazette & F. Morfoisse & J. Galitzky & A. Bouloumié & M. Dubourdeau & B. Chaput & N. Fazille, 2024. "15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Girolamo Di Maio & Ines Villano & Ciro Rosario Ilardi & Antonietta Messina & Vincenzo Monda & Ashlei Clara Iodice & Chiara Porro & Maria Antonietta Panaro & Sergio Chieffi & Giovanni Messina & Marcell, 2023. "Mechanisms of Transmission and Processing of Pain: A Narrative Review," IJERPH, MDPI, vol. 20(4), pages 1-19, February.
    5. Hidenori Moriyama & Jin Endo & Masaharu Kataoka & Yuta Shimanaka & Nozomu Kono & Yuki Sugiura & Shinichi Goto & Hiroki Kitakata & Takahiro Hiraide & Naohiro Yoshida & Sarasa Isobe & Tsunehisa Yamamoto, 2022. "Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. E. A. Monson & K. M. Crosse & M. Duan & W. Chen & R. D. O’Shea & L. M. Wakim & J. M. Carr & D. R. Whelan & K. J. Helbig, 2021. "Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    7. Isaac Francos-Quijorna & Marina Sánchez-Petidier & Emily R. Burnside & Smaranda R. Badea & Abel Torres-Espin & Lucy Marshall & Fred Winter & Joost Verhaagen & Victoria Moreno-Manzano & Elizabeth J. Br, 2022. "Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    8. Muriel Ramírez-Santana & Rodrigo Zapata Barra & Marcela Ñunque González & José Miguel Müller & Juan Enrique Vásquez & Franco Ravera & Gustavo Lago & Eduardo Cañón & Daniella Castañeda & Madelaine Prad, 2022. "Inverse Association between Omega-3 Index and Severity of COVID-19: A Case–Control Study," IJERPH, MDPI, vol. 19(11), pages 1-11, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3103-:d:1064053. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.