IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7268d10.1038_nature08541.html
   My bibliography  Save this article

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Author

Listed:
  • Matthew Spite

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Lucy V. Norling

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Lisa Summers

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Rong Yang

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dianne Cooper

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Nicos A. Petasis

    (University of Southern California, Los Angeles, California 90089, USA)

  • Roderick J. Flower

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Mauro Perretti

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Charles N. Serhan

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Anti-inflammatory activity of resolvin D2 Resolvins, locally acting factors derived from omega-3 fatty acids, have been recognized as inflammation-resolving mediators. Experiments in a mouse abdominal sepsis model now show that resolvin D2 (RvD2) inhibits neutrophil trafficking to inflammatory sites and decreases leukocyte interactions with endothelial cells in a nitric oxide-dependent manner. RvD2's cellular and molecular actions translated to a dramatic increased survival. This work points to RvD2 as a potent anti-inflammatory agent and suggests new therapeutic approaches that do not compromise host defences.

Suggested Citation

  • Matthew Spite & Lucy V. Norling & Lisa Summers & Rong Yang & Dianne Cooper & Nicos A. Petasis & Roderick J. Flower & Mauro Perretti & Charles N. Serhan, 2009. "Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis," Nature, Nature, vol. 461(7268), pages 1287-1291, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08541
    DOI: 10.1038/nature08541
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08541
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08541?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.
    2. Junio Dort & Zakaria Orfi & Paul Fabre & Thomas Molina & Talita C. Conte & Karine Greffard & Ornella Pellerito & Jean-François Bilodeau & Nicolas A. Dumont, 2021. "Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08541. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.