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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

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  • Matthew Spite

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Lucy V. Norling

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Lisa Summers

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Rong Yang

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dianne Cooper

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Nicos A. Petasis

    (University of Southern California, Los Angeles, California 90089, USA)

  • Roderick J. Flower

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Mauro Perretti

    (William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London)

  • Charles N. Serhan

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Anti-inflammatory activity of resolvin D2 Resolvins, locally acting factors derived from omega-3 fatty acids, have been recognized as inflammation-resolving mediators. Experiments in a mouse abdominal sepsis model now show that resolvin D2 (RvD2) inhibits neutrophil trafficking to inflammatory sites and decreases leukocyte interactions with endothelial cells in a nitric oxide-dependent manner. RvD2's cellular and molecular actions translated to a dramatic increased survival. This work points to RvD2 as a potent anti-inflammatory agent and suggests new therapeutic approaches that do not compromise host defences.

Suggested Citation

  • Matthew Spite & Lucy V. Norling & Lisa Summers & Rong Yang & Dianne Cooper & Nicos A. Petasis & Roderick J. Flower & Mauro Perretti & Charles N. Serhan, 2009. "Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis," Nature, Nature, vol. 461(7268), pages 1287-1291, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08541
    DOI: 10.1038/nature08541
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    Cited by:

    1. Junio Dort & Zakaria Orfi & Paul Fabre & Thomas Molina & Talita C. Conte & Karine Greffard & Ornella Pellerito & Jean-François Bilodeau & Nicolas A. Dumont, 2021. "Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Jennifer K Frediani & Dean P Jones & Nestan Tukvadze & Karan Uppal & Eka Sanikidze & Maia Kipiani & ViLinh T Tran & Gautam Hebbar & Douglas I Walker & Russell R Kempker & Shaheen S Kurani & Romain A C, 2014. "Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-9, October.

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