Deploying digital health data to optimize influenza surveillance at national and local scales

The surveillance of influenza activity is critical to early detection of epidemics and pandemics and the design of disease control strategies. Case reporting through a voluntary network of sentinel physicians is a commonly used method of passive surveillance for monitoring rates of influenza-like illness (ILI) worldwide. Despite its ubiquity, little attention has been given to the processes underlying the observation, collection, and spatial aggregation of sentinel surveillance data, and its subsequent effects on epidemiological understanding. We harnessed the high specificity of diagnosis codes in medical claims from a database that represented 2.5 billion visits from upwards of 120,000 United States healthcare providers each year. Among influenza seasons from 2002-2009 and the 2009 pandemic, we simulated limitations of sentinel surveillance systems such as low coverage and coarse spatial resolution, and performed Bayesian inference to probe the robustness of ecological inference and spatial prediction of disease burden. Our models suggest that a number of socio-environmental factors, in addition to local population interactions, state-specific health policies, as well as sampling effort may be responsible for the spatial patterns in U.S. sentinel ILI surveillance. In addition, we find that biases related to spatial aggregation were accentuated among areas with more heterogeneous disease risk, and sentinel systems designed with fixed reporting locations across seasons provided robust inference and prediction. With the growing availability of health-associated big data worldwide, our results suggest mechanisms for optimizing digital data streams to complement traditional surveillance in developed settings and enhance surveillance opportunities in developing countries.Author summary: Influenza contributes substantially to global morbidity and mortality each year, and epidemiological surveillance for influenza is typically conducted by sentinel physicians and health care providers recruited to report cases of influenza-like illness. While population coverage and representativeness, and geographic distribution are considered during sentinel provider recruitment, systems cannot always achieve these standards due to the administrative burdens of data collection. We present spatial estimates of influenza disease burden across United States counties by leveraging the volume and fine spatial resolution of medical claims data, and existing socio-environmental hypotheses about the determinants of influenza disease disease burden. Using medical claims as a testbed, this study adds to literature on the optimization of surveillance system design by considering conditions of limited reporting and spatial aggregation. We highlight the importance of considering sampling biases and reporting locations when interpreting surveillance data, and suggest that local mobility and regional policies may be critical to understanding the spatial distribution of reported influenza-like illness.