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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Author

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  • Yupeng Wang

    (College of Biological Sciences, China Agricultural University
    National Institute of Biological Sciences)

  • Wenqing Gao

    (College of Biological Sciences, China Agricultural University
    National Institute of Biological Sciences)

  • Xuyan Shi

    (College of Biological Sciences, China Agricultural University
    National Institute of Biological Sciences)

  • Jingjin Ding

    (National Institute of Biological Sciences
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Wang Liu

    (National Institute of Biological Sciences)

  • Huabin He

    (National Institute of Biological Sciences)

  • Kun Wang

    (National Institute of Biological Sciences)

  • Feng Shao

    (National Institute of Biological Sciences
    National Institute of Biological Sciences, Collaborative Innovation Center for Cancer Medicine)

Abstract

Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.

Suggested Citation

  • Yupeng Wang & Wenqing Gao & Xuyan Shi & Jingjin Ding & Wang Liu & Huabin He & Kun Wang & Feng Shao, 2017. "Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin," Nature, Nature, vol. 547(7661), pages 99-103, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7661:d:10.1038_nature22393
    DOI: 10.1038/nature22393
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    2. Si-Jia Sun & Xiao-Dong Jiao & Zhi-Gang Chen & Qi Cao & Jia-Hui Zhu & Qi-Rui Shen & Yi Liu & Zhen Zhang & Fang-Fang Xu & Yu Shi & Jie Tong & Shen-Xi Ouyang & Jiang-Tao Fu & Yi Zhao & Jun Ren & Dong-Jie, 2024. "Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    3. Joo-Hui Han & Rajendra Karki & R. K. Subbarao Malireddi & Raghvendra Mall & Roman Sarkar & Bhesh Raj Sharma & Jonathon Klein & Harmut Berns & Harshan Pisharath & Shondra M. Pruett-Miller & Sung-Jin Ba, 2024. "NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
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    5. Shuo Wang & An Song & Jun Xie & Yuan-Yuan Wang & Wen-Da Wang & Meng-Jie Zhang & Zhi-Zhong Wu & Qi-Chao Yang & Hao Li & Junjie Zhang & Zhi-Jun Sun, 2024. "Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
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    9. Zhaoting Li & Fanyi Mo & Yixin Wang & Wen Li & Yu Chen & Jun Liu & Ting-Jing Chen-Mayfield & Quanyin Hu, 2022. "Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Chaiheon Lee & Mingyu Park & W. C. Bhashini Wijesinghe & Seungjin Na & Chae Gyu Lee & Eunhye Hwang & Gwangsu Yoon & Jeong Kyeong Lee & Deok-Ho Roh & Yoon Hee Kwon & Jihyeon Yang & Sebastian A. Hughes , 2024. "Oxidative photocatalysis on membranes triggers non-canonical pyroptosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
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    12. Zhu, Ligang & Li, Xiang & Xu, Fei & Yin, Zhiyong & Jin, Jun & Liu, Zhilong & Qi, Hong & Shuai, Jianwei, 2022. "Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).
    13. Dao-Gong Zhang & Wen-Qian Yu & Jia-Hui Liu & Li-Gang Kong & Na Zhang & Yong-Dong Song & Xiao-Fei Li & Zhao-Min Fan & Ya-Feng Lyu & Na Li & Hai-Bo Wang, 2023. "Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    14. Yuanyuan Wei & Beidi Lan & Tao Zheng & Lin Yang & Xiaoxia Zhang & Lele Cheng & Gulinigaer Tuerhongjiang & Zuyi Yuan & Yue Wu, 2023. "GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
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    16. Yuan Lu & Wenbo He & Xin Huang & Yu He & Xiaojuan Gou & Xiaoke Liu & Zhe Hu & Weize Xu & Khaista Rahman & Shan Li & Sheng Hu & Jie Luo & Gang Cao, 2021. "Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    17. Chen Ni & Xiaohan Lou & Xiaohan Yao & Linlin Wang & Jiajia Wan & Xixi Duan & Jialu Liang & Kaili Zhang & Yuanyuan Yang & Li Zhang & Chanjun Sun & Zhenzhen Li & Ming Wang & Linyu Zhu & Dekang Lv & Zhih, 2022. "ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    18. Stefania A. Mari & Kristyna Pluhackova & Joka Pipercevic & Matthew Leipner & Sebastian Hiller & Andreas Engel & Daniel J. Müller, 2022. "Gasdermin-A3 pore formation propagates along variable pathways," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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