IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v477y2011i7365d10.1038_nature10388.html
   My bibliography  Save this article

Antibiotic resistance is ancient

Author

Listed:
  • Vanessa M. D’Costa

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Christine E. King

    (McMaster Ancient DNA Centre, McMaster University
    McMaster University)

  • Lindsay Kalan

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Mariya Morar

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Wilson W. L. Sung

    (McMaster University)

  • Carsten Schwarz

    (McMaster Ancient DNA Centre, McMaster University)

  • Duane Froese

    (University of Alberta)

  • Grant Zazula

    (Yukon Palaeontology Program, Yukon Government, PO Box 2703)

  • Fabrice Calmels

    (University of Alberta)

  • Regis Debruyne

    (Muséum National d’Histoire Naturelle, UMR 7206 Eco-anthropologie, 57 rue Cuvier, CP139)

  • G. Brian Golding

    (McMaster University)

  • Hendrik N. Poinar

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster Ancient DNA Centre, McMaster University
    McMaster University)

  • Gerard D. Wright

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

Abstract

The roots of antibiotic resistance Antibiotic resistance is thought to have evolved long before naturally occurring antibiotics and their derivatives were used to treat human disease, but direct evidence for genes that encode resistance has been lacking. Now, an ancient vancomycin-resistance gene has been recovered from 30,000-year-old samples of Siberian permafrost, and the three-dimensional structure of its product has been compared with that of its modern counterpart. There are minor structural differences between the ancient and modern versions, but the differences are not reflected in enzyme function.

Suggested Citation

  • Vanessa M. D’Costa & Christine E. King & Lindsay Kalan & Mariya Morar & Wilson W. L. Sung & Carsten Schwarz & Duane Froese & Grant Zazula & Fabrice Calmels & Regis Debruyne & G. Brian Golding & Hendri, 2011. "Antibiotic resistance is ancient," Nature, Nature, vol. 477(7365), pages 457-461, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10388
    DOI: 10.1038/nature10388
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10388
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10388?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Stacy Slobodiuk & Caitlin Niven & Greer Arthur & Siddhartha Thakur & Ayse Ercumen, 2021. "Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review," IJERPH, MDPI, vol. 18(21), pages 1-19, October.
    2. Na Li & Hongna Li & Changxiong Zhu & Chong Liu & Guofeng Su & Jianguo Chen, 2022. "Controlling AMR in the Pig Industry: Is It Enough to Restrict Heavy Metals?," IJERPH, MDPI, vol. 19(18), pages 1-12, September.
    3. Sharon P. Nappier & Krista Liguori & Audrey M. Ichida & Jill R. Stewart & Kaedra R. Jones, 2020. "Antibiotic Resistance in Recreational Waters: State of the Science," IJERPH, MDPI, vol. 17(21), pages 1-28, October.
    4. Rita Batista & Margarida Saraiva & Teresa Lopes & Leonor Silveira & Anabela Coelho & Rosália Furtado & Rita Castro & Cristina Belo Correia & David Rodrigues & Pedro Henriques & Sara Lóio & Vanessa Soe, 2022. "Genotypic and Phenotypic Characterization of Pathogenic Escherichia coli , Salmonella spp., and Campylobacter spp., in Free-Living Birds in Mainland Portugal," IJERPH, MDPI, vol. 20(1), pages 1-14, December.
    5. Nolonwabo Nontongana & Timothy Sibanda & Elvis Ngwenya & Anthony I. Okoh, 2014. "Prevalence and Antibiogram Profiling of Escherichia coli Pathotypes Isolated from the Kat River and the Fort Beaufort Abstraction Water," IJERPH, MDPI, vol. 11(8), pages 1-15, August.
    6. Valentin Duvauchelle & Elsa Causse & Julien Michon & Patrick Rateau & Karine Weiss & Patrick Meffre & Zohra Benfodda, 2021. "Evaluation of Knowledge and Risk Perception about Antibiotic Resistance in Biology and Mathematics Young Students in Nîmes University in France," IJERPH, MDPI, vol. 18(18), pages 1-12, September.
    7. Laura C. Scott & Nicholas Lee & Tiong Gim Aw, 2020. "Antibiotic Resistance in Minimally Human-Impacted Environments," IJERPH, MDPI, vol. 17(11), pages 1-12, June.
    8. Asit Kumar Chakraborty, 2017. "Mechanisms of AMR: Mdr Genes and Antibiotics Decoys Retard the New Antibiotic Discovery against Superbugs," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(1), pages 1-5, June.
    9. Shahnawaz Hassan & Zulaykha Khurshid & Sabreena & Bikram Singh Bali & Bashir Ah Ganai & R. Z. Sayyed & Peter Poczai & Muzafar Zaman, 2022. "A Critical Assessment of the Congruency between Environmental DNA and Palaeoecology for the Biodiversity Monitoring and Palaeoenvironmental Reconstruction," IJERPH, MDPI, vol. 19(15), pages 1-25, August.
    10. Merja Ahonen & Anne Kahru & Angela Ivask & Kaja Kasemets & Siiri Kõljalg & Paride Mantecca & Ivana Vinković Vrček & Minna M. Keinänen-Toivola & Francy Crijns, 2017. "Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI," IJERPH, MDPI, vol. 14(4), pages 1-23, March.
    11. Milva Pepi & Silvano Focardi, 2021. "Antibiotic-Resistant Bacteria in Aquaculture and Climate Change: A Challenge for Health in the Mediterranean Area," IJERPH, MDPI, vol. 18(11), pages 1-31, May.
    12. Łukasz Jałowiecki & Jakub Hubeny & Monika Harnisz & Grażyna Płaza, 2021. "Seasonal and Technological Shifts of the WHO Priority Multi-Resistant Pathogens in Municipal Wastewater Treatment Plant and Its Receiving Surface Water: A Case Study," IJERPH, MDPI, vol. 19(1), pages 1-13, December.
    13. Iyiola Olatunji Oladunjoye & Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Mona Said El-Sherbini, 2022. "Planetary Health and Traditional Medicine: A Potential Synergistic Approach to Tackle Antimicrobial Resistance," Challenges, MDPI, vol. 13(1), pages 1-10, June.
    14. Na Li & Chong Liu & Zhiguo Zhang & Hongna Li & Tingting Song & Ting Liang & Binxu Li & Luyao Li & Shuo Feng & Qianqian Su & Jing Ye & Changxiong Zhu, 2019. "Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry," IJERPH, MDPI, vol. 16(24), pages 1-19, December.
    15. Ming Ni & Antoine L Decrulle & Fanette Fontaine & Alice Demarez & Francois Taddei & Ariel B Lindner, 2012. "Pre-Disposition and Epigenetics Govern Variation in Bacterial Survival upon Stress," PLOS Genetics, Public Library of Science, vol. 8(12), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10388. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.