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Integrating time from experience in the lateral entorhinal cortex

Author

Listed:
  • Albert Tsao

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU
    Stanford University)

  • Jørgen Sugar

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU)

  • Li Lu

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU
    Baylor College of Medicine)

  • Cheng Wang

    (Johns Hopkins University)

  • James J. Knierim

    (Johns Hopkins University)

  • May-Britt Moser

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU)

  • Edvard I. Moser

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU)

Abstract

The encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal–entorhinal circuits is unclear. Here we show in freely foraging rats that temporal information is robustly encoded across time scales from seconds to hours within the overall population state of the lateral entorhinal cortex. Similarly pronounced encoding of time was not present in the medial entorhinal cortex or in hippocampal areas CA3–CA1. When animals’ experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved. The findings suggest that populations of lateral entorhinal cortex neurons represent time inherently through the encoding of experience. This representation of episodic time may be integrated with spatial inputs from the medial entorhinal cortex in the hippocampus, allowing the hippocampus to store a unified representation of what, where and when.

Suggested Citation

  • Albert Tsao & Jørgen Sugar & Li Lu & Cheng Wang & James J. Knierim & May-Britt Moser & Edvard I. Moser, 2018. "Integrating time from experience in the lateral entorhinal cortex," Nature, Nature, vol. 561(7721), pages 57-62, September.
    • Handle: RePEc:nat:nature:v:561:y:2018:i:7721:d:10.1038_s41586-018-0459-6
    DOI: 10.1038/s41586-018-0459-6
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    Citations

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    Cited by:

    1. Sina Mackay & Thomas P. Reber & Marcel Bausch & Jan Boström & Christian E. Elger & Florian Mormann, 2024. "Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Jacob L. S. Bellmund & Lorena Deuker & Nicole D. Montijn & Christian F. Doeller, 2022. "Mnemonic construction and representation of temporal structure in the hippocampal formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Futing Zou & Guo Wanjia & Emily J. Allen & Yihan Wu & Ian Charest & Thomas Naselaris & Kendrick Kay & Brice A. Kuhl & J. Benjamin Hutchinson & Sarah DuBrow, 2023. "Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Babak Shahbaba & Lingge Li & Forest Agostinelli & Mansi Saraf & Keiland W. Cooper & Derenik Haghverdian & Gabriel A. Elias & Pierre Baldi & Norbert J. Fortin, 2022. "Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Krishna Choudhary & Sven Berberich & Thomas T. G. Hahn & James M. McFarland & Mayank R. Mehta, 2024. "Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Wenqi Chen & Jiejunyi Liang & Qiyun Wu & Yunyun Han, 2024. "Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Xiaxia Xu & Lingzhen Song & Rebecca Kringel & Ileana L. Hanganu-Opatz, 2021. "Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    8. Eleanor Spens & Neil Burgess, 2024. "A generative model of memory construction and consolidation," Nature Human Behaviour, Nature, vol. 8(3), pages 526-543, March.

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