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Goal-oriented representations in the human hippocampus during planning and navigation

Author

Listed:
  • Jordan Crivelli-Decker

    (University of California
    University of California)

  • Alex Clarke

    (University of Cambridge)

  • Seongmin A. Park

    (University of California
    University of California)

  • Derek J. Huffman

    (University of California
    Colby College)

  • Erie D. Boorman

    (University of California
    University of Cambridge)

  • Charan Ranganath

    (University of California
    University of California)

Abstract

Recent work in cognitive and systems neuroscience has suggested that the hippocampus might support planning, imagination, and navigation by forming cognitive maps that capture the abstract structure of physical spaces, tasks, and situations. Navigation involves disambiguating similar contexts, and the planning and execution of a sequence of decisions to reach a goal. Here, we examine hippocampal activity patterns in humans during a goal-directed navigation task to investigate how contextual and goal information are incorporated in the construction and execution of navigational plans. During planning, hippocampal pattern similarity is enhanced across routes that share a context and a goal. During navigation, we observe prospective activation in the hippocampus that reflects the retrieval of pattern information related to a key-decision point. These results suggest that, rather than simply representing overlapping associations or state transitions, hippocampal activity patterns are shaped by context and goals.

Suggested Citation

  • Jordan Crivelli-Decker & Alex Clarke & Seongmin A. Park & Derek J. Huffman & Erie D. Boorman & Charan Ranganath, 2023. "Goal-oriented representations in the human hippocampus during planning and navigation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35967-6
    DOI: 10.1038/s41467-023-35967-6
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    References listed on IDEAS

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    1. Jeanette A Mumford & Jean-Baptiste Poline & Russell A Poldrack, 2015. "Orthogonalization of Regressors in fMRI Models," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-11, April.
    2. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
    3. Brad E. Pfeiffer & David J. Foster, 2013. "Hippocampal place-cell sequences depict future paths to remembered goals," Nature, Nature, vol. 497(7447), pages 74-79, May.
    4. Hiroshi T. Ito & Sheng-Jia Zhang & Menno P. Witter & Edvard I. Moser & May-Britt Moser, 2015. "A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation," Nature, Nature, vol. 522(7554), pages 50-55, June.
    5. Halle R. Dimsdale-Zucker & Maureen Ritchey & Arne D. Ekstrom & Andrew P. Yonelinas & Charan Ranganath, 2018. "CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    6. Jacob L. S. Bellmund & Lorena Deuker & Nicole D. Montijn & Christian F. Doeller, 2022. "Mnemonic construction and representation of temporal structure in the hippocampal formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Dmitriy Aronov & Rhino Nevers & David W. Tank, 2017. "Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit," Nature, Nature, vol. 543(7647), pages 719-722, March.
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    Cited by:

    1. Hannah Tarder-Stoll & Christopher Baldassano & Mariam Aly, 2024. "The brain hierarchically represents the past and future during multistep anticipation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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