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Distinct codes for environment structure and symmetry in postrhinal and retrosplenial cortices

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  • Patrick A. LaChance

    (Boston University)

  • Michael E. Hasselmo

    (Boston University)

Abstract

Complex sensory information arrives in the brain from an animal’s first-person (‘egocentric’) perspective. However, animals can efficiently navigate as if referencing map-like (‘allocentric’) representations. The postrhinal (POR) and retrosplenial (RSC) cortices are thought to mediate between sensory input and internal maps, combining egocentric representations of physical cues with allocentric head direction (HD) information. Here we show that neurons in the POR and RSC of female Long-Evans rats are tuned to distinct but complementary aspects of local space. Egocentric bearing (EB) cells recorded in square and L-shaped environments reveal that RSC cells encode local geometric features, while POR cells encode a more global account of boundary geometry. Additionally, POR HD cells can incorporate egocentric information to fire in two opposite directions with two oppositely placed identical visual landmarks, while only a subset of RSC HD cells possess this property. Entorhinal grid and HD cells exhibit consistently allocentric spatial firing properties. These results reveal significant regional differences in the neural encoding of spatial reference frames.

Suggested Citation

  • Patrick A. LaChance & Michael E. Hasselmo, 2024. "Distinct codes for environment structure and symmetry in postrhinal and retrosplenial cortices," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52315-4
    DOI: 10.1038/s41467-024-52315-4
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    References listed on IDEAS

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    1. Julija Krupic & Marius Bauza & Stephen Burton & Caswell Barry & John O’Keefe, 2015. "Grid cell symmetry is shaped by environmental geometry," Nature, Nature, vol. 518(7538), pages 232-235, February.
    2. Torkel Hafting & Marianne Fyhn & Sturla Molden & May-Britt Moser & Edvard I. Moser, 2005. "Microstructure of a spatial map in the entorhinal cortex," Nature, Nature, vol. 436(7052), pages 801-806, August.
    3. Dario Campagner & Ruben Vale & Yu Lin Tan & Panagiota Iordanidou & Oriol Pavón Arocas & Federico Claudi & A. Vanessa Stempel & Sepiedeh Keshavarzi & Rasmus S. Petersen & Troy W. Margrie & Tiago Branco, 2023. "A cortico-collicular circuit for orienting to shelter during escape," Nature, Nature, vol. 613(7942), pages 111-119, January.
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