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Immunocompatible elastomer with increased resistance to the foreign body response

Author

Listed:
  • Xianchi Zhou

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Zhouyu Lu

    (Zhejiang University)

  • Wenzhong Cao

    (Zhejiang University)

  • Zihao Zhu

    (Zhejiang University)

  • Yifeng Chen

    (Zhejiang University)

  • Yanwen Ni

    (Zhejiang University)

  • Zuolong Liu

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Fan Jia

    (Zhejiang University)

  • Yang Ye

    (Zhejiang University)

  • Haijie Han

    (Zhejiang University)

  • Ke Yao

    (Zhejiang University)

  • Weifeng Liu

    (Zhejiang University)

  • Youxiang Wang

    (Zhejiang University)

  • Jian Ji

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Peng Zhang

    (Zhejiang University School of Medicine
    Zhejiang University)

Abstract

Polymeric elastomers are extensively employed to fabricate implantable medical devices. However, implantation of the elastomers can induce a strong immune rejection known as the foreign body response (FBR), diminishing their efficacy. Herein, we present a group of immunocompatible elastomers, termed easy-to-synthesize vinyl-based anti-FBR dense elastomers (EVADE). EVADE materials effectively suppress the inflammation and capsule formation in subcutaneous models of rodents and non-human primates for at least one year and two months, respectively. Implantation of EVADE materials significantly reduces the expression of inflammation-related proteins S100A8/A9 in adjacent tissues compared to polydimethylsiloxane. We also show that inhibition or knockout of S100A8/A9 leads to substantial attenuation of fibrosis in mice, suggesting a target for fibrosis inhibition. Continuous subcutaneous insulin infusion (CSII) catheters constructed from EVADE elastomers demonstrate significantly improved longevity and performance compared to commercial catheters. The EVADE materials reported here may enhance and extend function in various medical devices by resisting the local immune responses.

Suggested Citation

  • Xianchi Zhou & Zhouyu Lu & Wenzhong Cao & Zihao Zhu & Yifeng Chen & Yanwen Ni & Zuolong Liu & Fan Jia & Yang Ye & Haijie Han & Ke Yao & Weifeng Liu & Youxiang Wang & Jian Ji & Peng Zhang, 2024. "Immunocompatible elastomer with increased resistance to the foreign body response," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52023-z
    DOI: 10.1038/s41467-024-52023-z
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    References listed on IDEAS

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    1. Donghui Zhang & Qi Chen & Yufang Bi & Haodong Zhang & Minzhang Chen & Jianglin Wan & Chao Shi & Wenjing Zhang & Junyu Zhang & Zhongqian Qiao & Jin Li & Shengfu Chen & Runhui Liu, 2021. "Bio-inspired poly-DL-serine materials resist the foreign-body response," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Jinxing Li & Yuxin Liu & Lei Yuan & Baibing Zhang & Estelle Spear Bishop & Kecheng Wang & Jing Tang & Yu-Qing Zheng & Wenhui Xu & Simiao Niu & Levent Beker & Thomas L. Li & Gan Chen & Modupeola Diyaol, 2022. "A tissue-like neurotransmitter sensor for the brain and gut," Nature, Nature, vol. 606(7912), pages 94-101, June.
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