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Bio-inspired poly-DL-serine materials resist the foreign-body response

Author

Listed:
  • Donghui Zhang

    (East China University of Science and Technology)

  • Qi Chen

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Yufang Bi

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Haodong Zhang

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Minzhang Chen

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Jianglin Wan

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Chao Shi

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Wenjing Zhang

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Junyu Zhang

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Zhongqian Qiao

    (Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

  • Jin Li

    (Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine)

  • Shengfu Chen

    (College of Chemical and Biological Engineering, Zhejiang University)

  • Runhui Liu

    (East China University of Science and Technology
    Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology)

Abstract

Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

Suggested Citation

  • Donghui Zhang & Qi Chen & Yufang Bi & Haodong Zhang & Minzhang Chen & Jianglin Wan & Chao Shi & Wenjing Zhang & Junyu Zhang & Zhongqian Qiao & Jin Li & Shengfu Chen & Runhui Liu, 2021. "Bio-inspired poly-DL-serine materials resist the foreign-body response," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25581-9
    DOI: 10.1038/s41467-021-25581-9
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    Cited by:

    1. Xianchi Zhou & Zhouyu Lu & Wenzhong Cao & Zihao Zhu & Yifeng Chen & Yanwen Ni & Zuolong Liu & Fan Jia & Yang Ye & Haijie Han & Ke Yao & Weifeng Liu & Youxiang Wang & Jian Ji & Peng Zhang, 2024. "Immunocompatible elastomer with increased resistance to the foreign body response," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. William Whyte & Debkalpa Goswami & Sophie X. Wang & Yiling Fan & Niamh A. Ward & Ruth E. Levey & Rachel Beatty & Scott T. Robinson & Declan Sheppard & Raymond O’Connor & David S. Monahan & Lesley Tras, 2022. "Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Donghui Zhang & Jingjing Liu & Qi Chen & Weinan Jiang & Yibing Wang & Jiayang Xie & Kaiqian Ma & Chao Shi & Haodong Zhang & Minzhang Chen & Jianglin Wan & Pengcheng Ma & Jingcheng Zou & Wenjing Zhang , 2021. "A sandcastle worm-inspired strategy to functionalize wet hydrogels," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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