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A tissue-like neurotransmitter sensor for the brain and gut

Author

Listed:
  • Jinxing Li

    (Stanford University
    Michigan State University)

  • Yuxin Liu

    (Stanford University)

  • Lei Yuan

    (Stanford University)

  • Baibing Zhang

    (Stanford University)

  • Estelle Spear Bishop

    (Stanford University School of Medicine)

  • Kecheng Wang

    (Stanford University)

  • Jing Tang

    (Stanford University)

  • Yu-Qing Zheng

    (Stanford University)

  • Wenhui Xu

    (Stanford University)

  • Simiao Niu

    (Stanford University)

  • Levent Beker

    (Stanford University)

  • Thomas L. Li

    (Stanford University
    Stanford University)

  • Gan Chen

    (Stanford University)

  • Modupeola Diyaolu

    (Stanford University)

  • Anne-Laure Thomas

    (Stanford University)

  • Vittorio Mottini

    (Stanford University
    Michigan State University)

  • Jeffrey B.-H. Tok

    (Stanford University)

  • James C. Y. Dunn

    (Stanford University
    Stanford University)

  • Bianxiao Cui

    (Stanford University)

  • Sergiu P. Pașca

    (Stanford University
    Stanford University)

  • Yi Cui

    (Stanford University)

  • Aida Habtezion

    (Stanford University School of Medicine)

  • Xiaoke Chen

    (Stanford University)

  • Zhenan Bao

    (Stanford University)

Abstract

Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract1–3. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease1–3. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain–gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.

Suggested Citation

  • Jinxing Li & Yuxin Liu & Lei Yuan & Baibing Zhang & Estelle Spear Bishop & Kecheng Wang & Jing Tang & Yu-Qing Zheng & Wenhui Xu & Simiao Niu & Levent Beker & Thomas L. Li & Gan Chen & Modupeola Diyaol, 2022. "A tissue-like neurotransmitter sensor for the brain and gut," Nature, Nature, vol. 606(7912), pages 94-101, June.
  • Handle: RePEc:nat:nature:v:606:y:2022:i:7912:d:10.1038_s41586-022-04615-2
    DOI: 10.1038/s41586-022-04615-2
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    Citations

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    Cited by:

    1. Tong Li & Zhidong Wei & Fei Jin & Yongjiu Yuan & Weiying Zheng & Lili Qian & Hongbo Wang & Lisha Hua & Juan Ma & Huanhuan Zhang & Huaduo Gu & Michael G. Irwin & Ting Wang & Steven Wang & Zuankai Wang , 2023. "Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Xinjian Xie & Zhonggang Xu & Xin Yu & Hong Jiang & Hongjiao Li & Wenqian Feng, 2023. "Liquid-in-liquid printing of 3D and mechanically tunable conductive hydrogels," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Kewang Nan & Kiwan Wong & Dengfeng Li & Binbin Ying & James C. McRae & Vivian R. Feig & Shubing Wang & Ningjie Du & Yuelong Liang & Qijiang Mao & Enjie Zhou & Yonglin Chen & Lei Sang & Kuanming Yao & , 2024. "An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Martin Hjort & Abdelrazek H. Mousa & David Bliman & Muhammad Anwar Shameem & Karin Hellman & Amit Singh Yadav & Peter Ekström & Fredrik Ek & Roger Olsson, 2023. "In situ assembly of bioresorbable organic bioelectronics in the brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Leiwen Mao & Yujie Han & Qi-Wei Zhang & Yang Tian, 2023. "Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    6. Xianchi Zhou & Zhouyu Lu & Wenzhong Cao & Zihao Zhu & Yifeng Chen & Yanwen Ni & Zuolong Liu & Fan Jia & Yang Ye & Haijie Han & Ke Yao & Weifeng Liu & Youxiang Wang & Jian Ji & Peng Zhang, 2024. "Immunocompatible elastomer with increased resistance to the foreign body response," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Sizhe Huang & Xinyue Liu & Shaoting Lin & Christopher Glynn & Kayla Felix & Atharva Sahasrabudhe & Collin Maley & Jingyi Xu & Weixuan Chen & Eunji Hong & Alfred J. Crosby & Qianbin Wang & Siyuan Rao, 2024. "Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Zhouheng Wang & Nanlin Shi & Yingchao Zhang & Ning Zheng & Haicheng Li & Yang Jiao & Jiahui Cheng & Yutong Wang & Xiaoqing Zhang & Ying Chen & Yihao Chen & Heling Wang & Tao Xie & Yijun Wang & Yinji M, 2023. "Conformal in-ear bioelectronics for visual and auditory brain-computer interfaces," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    9. Jung Min Lee & Young-Woo Pyo & Yeon Jun Kim & Jin Hee Hong & Yonghyeon Jo & Wonshik Choi & Dingchang Lin & Hong-Gyu Park, 2023. "The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Young-Geun Park & Yong Won Kwon & Chin Su Koh & Enji Kim & Dong Ha Lee & Sumin Kim & Jongmin Mun & Yeon-Mi Hong & Sanghoon Lee & Ju-Young Kim & Jae-Hyun Lee & Hyun Ho Jung & Jinwoo Cheon & Jin Woo Cha, 2024. "In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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