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Replay-triggered brain-wide activation in humans

Author

Listed:
  • Qi Huang

    (Beijing Normal University
    Chinese Institute for Brain Research)

  • Zhibing Xiao

    (Beijing Normal University
    Chinese Institute for Brain Research)

  • Qianqian Yu

    (Shenzhen University)

  • Yuejia Luo

    (Beijing Normal University
    Shenzhen University)

  • Jiahua Xu

    (Chinese Institute for Brain Research)

  • Yukun Qu

    (Beijing Normal University
    Chinese Institute for Brain Research)

  • Raymond Dolan

    (Beijing Normal University
    Max Planck University College London Centre for Computational Psychiatry and Ageing Research
    UCL)

  • Timothy Behrens

    (UCL
    University of Oxford
    UCL)

  • Yunzhe Liu

    (Beijing Normal University
    Chinese Institute for Brain Research)

Abstract

The consolidation of discrete experiences into a coherent narrative shapes the cognitive map, providing structured mental representations of our experiences. In this process, past memories are reactivated and replayed in sequence, fostering hippocampal-cortical dialogue. However, brain-wide engagement coinciding with sequential reactivation (or replay) of memories remains largely unexplored. In this study, employing simultaneous EEG-fMRI, we capture both the spatial and temporal dynamics of memory replay. We find that during mental simulation, past memories are replayed in fast sequences as detected via EEG. These transient replay events are associated with heightened fMRI activity in the hippocampus and medial prefrontal cortex. Replay occurrence strengthens functional connectivity between the hippocampus and the default mode network, a set of brain regions key to representing the cognitive map. On the other hand, when subjects are at rest following learning, memory reactivation of task-related items is stronger than that of pre-learning rest, and is also associated with heightened hippocampal activation and augmented hippocampal connectivity to the entorhinal cortex. Together, our findings highlight a distributed, brain-wide engagement associated with transient memory reactivation and its sequential replay.

Suggested Citation

  • Qi Huang & Zhibing Xiao & Qianqian Yu & Yuejia Luo & Jiahua Xu & Yukun Qu & Raymond Dolan & Timothy Behrens & Yunzhe Liu, 2024. "Replay-triggered brain-wide activation in humans," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51582-5
    DOI: 10.1038/s41467-024-51582-5
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    References listed on IDEAS

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