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De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis

Author

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  • Yingguo Li

    (Jiangsu University of Science and Technology)

  • Jialun He

    (Jiangsu University of Science and Technology)

  • Guilong Lu

    (Nanjing Tech University)

  • Chensheng Wang

    (Jiangsu University of Science and Technology)

  • Mengmeng Fu

    (Jiangsu University of Science and Technology)

  • Juan Deng

    (Jiangsu University of Science and Technology)

  • Fu Yang

    (Jiangsu University of Science and Technology)

  • Danfeng Jiang

    (Jiangsu University of Science and Technology)

  • Xiao Chen

    (Jiangsu University of Science and Technology)

  • Ziyi Yu

    (Nanjing Tech University)

  • Yan Liu

    (Shanghai Jiao Tong University)

  • Chao Yu

    (Jiangsu University of Science and Technology)

  • Yong Cui

    (Shanghai Jiao Tong University)

Abstract

Microflow catalysis is a cutting-edge approach to advancing chemical synthesis and manufacturing, but the challenge lies in developing efficient and stable multiphase catalysts. Here we showcase incorporating amine-containing metal-organic cages into automated microfluidic reactors through covalent bonds, enabling highly continuous flow catalysis. Two Fe4L4 tetrahedral cages bearing four uncoordinated amines were designed and synthesized. Post-synthetic modifications of the amine groups with 3-isocyanatopropyltriethoxysilane, introducing silane chains immobilized on the inner walls of the microfluidic reactor. The immobilized cages prove highly efficient for the reaction of anthranilamide with aldehydes, showing superior reactivity and recyclability relative to free cages. This superiority arises from the large cavity, facilitating substrate accommodation and conversion, a high mass transfer rate and stable covalent bonds between cage and microreactor. This study exemplifies the synergy of cages with microreactor technology, highlighting the benefits of heterogenous cages and the potential for future automated synthesis processes

Suggested Citation

  • Yingguo Li & Jialun He & Guilong Lu & Chensheng Wang & Mengmeng Fu & Juan Deng & Fu Yang & Danfeng Jiang & Xiao Chen & Ziyi Yu & Yan Liu & Chao Yu & Yong Cui, 2024. "De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51431-5
    DOI: 10.1038/s41467-024-51431-5
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    References listed on IDEAS

    as
    1. Jesús Mosquera & Bartosz Szyszko & Sarah K. Y. Ho & Jonathan R. Nitschke, 2017. "Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage," Nature Communications, Nature, vol. 8(1), pages 1-6, April.
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    4. Sha Chen & Kang Li & Fang Zhao & Lei Zhang & Mei Pan & Yan-Zhong Fan & Jing Guo & Jianying Shi & Cheng-Yong Su, 2016. "A metal-organic cage incorporating multiple light harvesting and catalytic centres for photochemical hydrogen production," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
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